Severe peripheral arteriosclerosis/cerebrovascular disease Active infection Malignancy Severely impaired renal function Severe systemic disorders, multiorgan failure Secondary disease with poor prognosis Intellectual impairment Pharmacologically irreversible pulmonary hypertension (→ proof of candidacy for LVAD with re-evaluation of haemodynamics under unloaded left ventricular conditions) BMI before a heart transplant >35 kg/m2 Persistent drug abuse