Advantages  Disadvantages  Problems to solve
HTx  Benefit in terms of long-term mortality
Better quality of life  Organ shortage
Precise immunomatching (HLA/ABO)
Organ rejection  Improvement in organ allocation
Preservation
Reducing ischaemia-reperfusion injury (e.g. OCS®)
Expand donor pool to potentially marginal donors
VAD  ‘Unlimited’ availability  Durability
Energy supply
Bleeding/thrombosis
Infection
Technical malfunction  Develop complete and durable intracorporeal devices
Transcutaneous energy transfer
Lower bleeding/thrombosis risk