Supplementary Fig. S7  (A–B) Effects of Nrf2 overexpression plasmid on protein levels of Nrf2, NQO1, HO-1, GCLC and ABCC5 in digoxin-treated SW1990/Gem and Panc-1/Gem cells. (C–D) Nrf2 overexpression plasmid could restore drug resistance of gemcitabine in digoxin-treated SW1990/Gem and Panc-1/Gem cells. Data were expressed as mean ± SD, and the results were representative of three independent experiments. Significant differences were indicated as ***P < 0.001 vs. control group.