Table 3 Associations between the 313-SNP PRS (PRS313) and Breast Cancer Risk by First-Degree Family History of Breast Cancer in the Combined Validation and Prospective Test Dataset
Model ER-Positive Disease ER-Negative Disease
ORa 95% CI ORa 95% CI
Association of PRS and Breast Cancer Risk by Family History
PRS unadjusted 1.67 1.62–1.72 1.44 1.37–1.54
PRS in women without family history 1.71 1.65–1.78 1.45 1.36–1.57
PRS in women with family history 1.55 1.48–1.65 1.40 1.27–1.55
Interaction between PRS and family history 0.91 0.85–0.97 (p = 0.004) 0.96 0.85–1.09 (p = 0.53)
Association between Family History and Breast Cancer Risk (Adjusted and Unadjusted for PRS)
Family history unadjusted for PRS 1.59 1.46–1.72 1.66 1.41–1.95
Family history adjusted for PRS 1.44 1.33–1.57 1.56 1.32–1.83
Association with breast cancer risk was tested for using logistic regression adjusting for study and ten PCs. For these analyses the validation and test datasets were combined. Analyses were restricted to women with known age and family history information. For ER-negative disease, 4,440 women with and 13,132 women without a family history of breast cancer were included in these analyses. For ER-positive disease, 6,787 women with and 17,351 women without a family history of breast cancer were included in these analyses.
a OR per 1 SD for the PRS.