The Treatment Response and Resistance in Psychosis (TRRIP) working group recently addressed these challenges (12). Members are researchers and clinicians who have expertise in TRS and attended specific TRRIP working group meetings at international schizophrenia and neuropsychopharmacology research conferences to establish criteria to standardize the definition of treatment resistance in schizophrenia. In addition to capturing a core definition of treatment resistance that can be included and shared across all clinical treatment guidelines worldwide, recommendations were also made on the importance of identification of all clinical sub-specifiers or symptom phenotypes common to TRS (12). The standardization of clinical criteria of TRS has been an important advancement and will benefit future TRS research and clinical translation.