Parvalbumin interneurons contribute to the inhibitory dysfunction in schizophrenia. Parvalbumin interneurons are fast-spiking inhibitory interneurons characterized by the calcium binding protein parvalbumin. These interneurons are innervated by excitatory glutamatergic cells and in turn their projections target the cell soma of excitatory pyramidal cells. This excitatory-inhibitory interplay is thought to give rise to the GBO, which is reflective of parvalbumin interneurons role in synchronizing large populations of excitatory cells. The GBO is disturbed in schizophrenia, and dysfunction within parvalbumin interneurons is thought to be central to these abnormalities.