PMC:6218602 / 24043-25144
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6218602","sourcedb":"PMC","sourceid":"6218602","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6218602","text":"Studies that have specifically compared patients with treatment responsive schizophrenia vs. TRS have reported greater global volumetric reductions of GM in treatment resistant and ultra-resistant patients. There have been consistent reports of reduced GM volumes predominantly within the dorsolateral prefrontal cortex (DLPFC) (53–56), as well as posterior cortical regions, such as the temporal cortex (53–56), parietal cortex (53, 56) and also within the occipital cortex (53, 55, 56) in TRS. Abnormalities in all regions of the corpus callosum as well as commissural and association long axonal fiber pathways connecting prefrontal, temporal, parietal and occipital regions have also been found, with reduced axonal integrity and more severe structural damage in both chronic illness and treatment-resistant populations (43, 57–59, 64). This evidence seems to suggest that on the spectrum of cellular and circuit disruption characteristic of schizophrenia in general, TRS may involve a more severe type of multi-dysconnectivity of brain networks that spans across almost every region of the brain.","tracks":[{"project":"2_test","denotations":[{"id":"30425662-25716781-41865378","span":{"begin":329,"end":331},"obj":"25716781"},{"id":"30425662-24321225-41865378","span":{"begin":329,"end":331},"obj":"24321225"},{"id":"30425662-17900778-41865378","span":{"begin":329,"end":331},"obj":"17900778"},{"id":"30425662-23721966-41865378","span":{"begin":329,"end":331},"obj":"23721966"},{"id":"30425662-25716781-41865379","span":{"begin":405,"end":407},"obj":"25716781"},{"id":"30425662-24321225-41865379","span":{"begin":405,"end":407},"obj":"24321225"},{"id":"30425662-17900778-41865379","span":{"begin":405,"end":407},"obj":"17900778"},{"id":"30425662-23721966-41865379","span":{"begin":405,"end":407},"obj":"23721966"},{"id":"30425662-25716781-41865380","span":{"begin":430,"end":432},"obj":"25716781"},{"id":"30425662-23721966-41865381","span":{"begin":434,"end":436},"obj":"23721966"},{"id":"30425662-25716781-41865382","span":{"begin":476,"end":478},"obj":"25716781"},{"id":"30425662-17900778-41865383","span":{"begin":480,"end":482},"obj":"17900778"},{"id":"30425662-23721966-41865384","span":{"begin":484,"end":486},"obj":"23721966"},{"id":"30425662-21300524-41865385","span":{"begin":825,"end":827},"obj":"21300524"},{"id":"30425662-18558643-41865386","span":{"begin":829,"end":831},"obj":"18558643"},{"id":"30425662-21138657-41865386","span":{"begin":829,"end":831},"obj":"21138657"},{"id":"30425662-24150571-41865386","span":{"begin":829,"end":831},"obj":"24150571"},{"id":"30425662-17587598-41865387","span":{"begin":836,"end":838},"obj":"17587598"}],"attributes":[{"subj":"30425662-25716781-41865378","pred":"source","obj":"2_test"},{"subj":"30425662-24321225-41865378","pred":"source","obj":"2_test"},{"subj":"30425662-17900778-41865378","pred":"source","obj":"2_test"},{"subj":"30425662-23721966-41865378","pred":"source","obj":"2_test"},{"subj":"30425662-25716781-41865379","pred":"source","obj":"2_test"},{"subj":"30425662-24321225-41865379","pred":"source","obj":"2_test"},{"subj":"30425662-17900778-41865379","pred":"source","obj":"2_test"},{"subj":"30425662-23721966-41865379","pred":"source","obj":"2_test"},{"subj":"30425662-25716781-41865380","pred":"source","obj":"2_test"},{"subj":"30425662-23721966-41865381","pred":"source","obj":"2_test"},{"subj":"30425662-25716781-41865382","pred":"source","obj":"2_test"},{"subj":"30425662-17900778-41865383","pred":"source","obj":"2_test"},{"subj":"30425662-23721966-41865384","pred":"source","obj":"2_test"},{"subj":"30425662-21300524-41865385","pred":"source","obj":"2_test"},{"subj":"30425662-18558643-41865386","pred":"source","obj":"2_test"},{"subj":"30425662-21138657-41865386","pred":"source","obj":"2_test"},{"subj":"30425662-24150571-41865386","pred":"source","obj":"2_test"},{"subj":"30425662-17587598-41865387","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#d993ec","default":true}]}]}}