PMC:6218602 / 23462-24042
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/6218602","sourcedb":"PMC","sourceid":"6218602","source_url":"https://www.ncbi.nlm.nih.gov/pmc/6218602","text":"The loss of neuronal elements that underlie the symptoms of both TRS and ultra-resistant schizophrenia (clozapine-resistant psychosis) may be more substantial than what is found in those patient phenotypes who have responded to antipsychotic treatment (51, 52). Volumetric, DTI and fMRI studies that have examined intra-regional brain morphology (53–56) inter-regional WM circuit integrity (43, 57–59), and functional connectivity (60–63) specific to TRS have consistently identified a disruption to frontal and temporal lobe regions and the major fiber bundles that connect them.","tracks":[{"project":"2_test","denotations":[{"id":"30425662-26948188-41865372","span":{"begin":253,"end":255},"obj":"26948188"},{"id":"30425662-25684554-41865373","span":{"begin":257,"end":259},"obj":"25684554"},{"id":"30425662-25716781-41865374","span":{"begin":347,"end":349},"obj":"25716781"},{"id":"30425662-24321225-41865374","span":{"begin":347,"end":349},"obj":"24321225"},{"id":"30425662-17900778-41865374","span":{"begin":347,"end":349},"obj":"17900778"},{"id":"30425662-23721966-41865374","span":{"begin":347,"end":349},"obj":"23721966"},{"id":"30425662-21300524-41865375","span":{"begin":391,"end":393},"obj":"21300524"},{"id":"30425662-18558643-41865376","span":{"begin":395,"end":397},"obj":"18558643"},{"id":"30425662-21138657-41865376","span":{"begin":395,"end":397},"obj":"21138657"},{"id":"30425662-24150571-41865376","span":{"begin":395,"end":397},"obj":"24150571"},{"id":"30425662-25468173-41865377","span":{"begin":432,"end":434},"obj":"25468173"},{"id":"30425662-20060103-41865377","span":{"begin":432,"end":434},"obj":"20060103"},{"id":"30425662-21791169-41865377","span":{"begin":432,"end":434},"obj":"21791169"},{"id":"30425662-22178083-41865377","span":{"begin":432,"end":434},"obj":"22178083"}],"attributes":[{"subj":"30425662-26948188-41865372","pred":"source","obj":"2_test"},{"subj":"30425662-25684554-41865373","pred":"source","obj":"2_test"},{"subj":"30425662-25716781-41865374","pred":"source","obj":"2_test"},{"subj":"30425662-24321225-41865374","pred":"source","obj":"2_test"},{"subj":"30425662-17900778-41865374","pred":"source","obj":"2_test"},{"subj":"30425662-23721966-41865374","pred":"source","obj":"2_test"},{"subj":"30425662-21300524-41865375","pred":"source","obj":"2_test"},{"subj":"30425662-18558643-41865376","pred":"source","obj":"2_test"},{"subj":"30425662-21138657-41865376","pred":"source","obj":"2_test"},{"subj":"30425662-24150571-41865376","pred":"source","obj":"2_test"},{"subj":"30425662-25468173-41865377","pred":"source","obj":"2_test"},{"subj":"30425662-20060103-41865377","pred":"source","obj":"2_test"},{"subj":"30425662-21791169-41865377","pred":"source","obj":"2_test"},{"subj":"30425662-22178083-41865377","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#9fec93","default":true}]}]}}