Topological graph features of the connectome. (A) The graph consists of “nodes” that represent single neurons or brain regions and are linked by “edges” illustrating their connection to each other via axonal projections. (B) The “degree” or number of edges and how close they are to each other “centrality” represents the interconnectivity of nodes. (C) Nodes having a high degree of edges and high centrality are knowns as “hubs.” Brain hubs “rich” in connectivity to each other and found centrally form the “rich club organization.” The rich club hubs found in cortical and frontal lobe regions of the brain are affected in schizophrenia.