With the advancement of neuroimaging techniques, such as positron emission tomography (PET) and MRI that are able to detail both anatomical and functional connectivity, the disconnection hypothesis of schizophrenia has been refined further. The modern-day disconnectivity hypothesis of schizophrenia initially emphasized the link between the signs and symptoms of schizophrenia and the dysfunctional integration between different cortical areas of the brain, directly related to the underlying abnormalities in neurons and synaptic functioning (25). Abnormal modulation of NMDA receptor function and impaired control of synaptic plasticity is thought to be the underlying key to dysfunction and directly contributes to an extended pattern of “dysconnection” of the structural and functional integration of the brain (26–30). Today, network scientists integrate the mathematical analysis of graph theory as a framework for studying and tracing these macro-scale brain networks through non-invasive neuroimaging and MRI methods (31–33). Through these methods they are able to create a “connectome,” the neuronal map of the brain's anatomical and functional connectivity architecture, and elucidate the complex organization of the neuronal elements that underlies brain function (31–34).