Meynert's student Carl Wernicke (1848–1905) further developed the disconnectivity theory of schizophrenia. Although he was best known for his theories regarding the neural circuits involved in higher cognitive functions and the neuropathology of aphasia, he also studied the neuroanatomical and functional aspects of schizophrenia. In his textbook Grundriss der Psychiatrie (Outlines of Psychiatry 1900) which was written based on detailed reviews of his clinical cases, he outlined his hypothesis that there is a deficiency in association fiber connectivity in schizophrenia that contributes to an over-activation of cortical sensory regions that can then lead to the development of psychosis (22).