Shown is an example of (A) a DNA-methylation site (cg00331210) that is associated with expression of a gene (FAM173A) that is not the most proximal to it and (B) a DNA-methylation site (cg00072720) associated with the expression of multiple genes (CLDN7 and ELP5). Each plot contains a gene track, where red arrows indicate the direction of transcription and a red diamond indicates the position of the pleiotropically significant DNA-methylation site. Circles and squares indicate the location of the gene expression probes that DNA-methylation sites were tested against. Color indicates the significance level of the SMR test (black to gray), and green indicates significant associations (p < 1.02 × 10−7). For significant associations, squares indicate tests that have non-significant heterogeneity (p > 0.05) and are indicative of pleiotropic associations.