Summary-Data-Based Mendelian Randomization (SMR) Analysis Using Quantitative Trait Loci Associated with DNA Methylation (mQTL) and Gene Expression (eQTL) Implicates a Role for LIME1 in Crohn Disease
Shown is a genomic region on chromosome 20 (chr20: 62335000–62371000) identified in a recent Crohn disease GWAS performed by Liu et al.51 Genes located in this region are shown at the top, exons are indicated by thicker bars, and the red arrows indicate the direction of transcription. The scatterplot depicts the –log10 p value (y axis) against genomic location (x axis) from the SMR analysis (where circles represent Illumina EPIC array DNA-methylation sites, squares represent gene expression probes, and solid green and red highlight those with a non-significant HEIDI test for DNA methylation and gene expression, respectively). The green and red horizontal lines represent the multiple-testing corrected threshold for the SMR test using mQTL and eQTL, respectively.