The net flux and efflux have often been interpreted using the simplest extension of the Michaelis–Menten description used for influx, i.e. (see e.g. [310, 323, 539]) leading to31 Teff=Tmax∗cisf/Kt+cisfand32 Tnet=Tinf-Teff=Tmaxcplasma/Kt+cplasma-cisf/Kt+cisf.