The concentration dependence of the rate of glucose influx, Tinf, has often been described empirically using the simplest form of Michaelis–Menten kinetics [310] 28 Tinf=Tmax∗cplasma/Kt+cplasmawhere Tmax is the maximum transport rate and Kt is the Michaelis constant for influx (t and T stand for “transport”). From this expression for the rate, the decrease in clearance with concentration is predicted to be29 CL=Tmax/Kt+cplasma.