Abraham et al. [165] applied this approach to the prediction of partition coefficients from water into a number of solvents, including n-octanol for which25 logKn-octanol/water=0.088+0.562R2-1.054π2H-3.46∑β2H+3.81Vxwhere the descriptors are: excess molar refraction, R2; polarizability, π2H; solute hydrogen bond basicity, β2H, which is summed over the appropriate groups in the molecule; and molecular volume, Vx. See [165] and references therein for the rationale for choosing these descriptors and their definitions. The volume term makes the largest contribution to the differences between the 18 substances considered [166] with the larger substances being more soluble in n-octanol.