It is interesting to note that Xie et al. [128] found the half-lives for both Aβ and inulin to be different when the mice were asleep as compared to when they were awake. In both conditions the rate constant was larger for Aβ than for inulin (see Table 5). The interpretation of these differences in rate constants between wakefulness and sleep has been considered in some detail in [146] and will not be considered further here.
Table 5 Rate constants for elimination of 125I-Aβ1-40, 125I-Aβ1-42 and inulin in mice
Rate constant/min−1
Shibtata et al. Bell et al. Xie et al. awake Xie et al. asleep
Inulin 0.0029 0.0024 0.006 0.016
Aβ1-40 0.027 0.0184 0.024 0.053
Aβ1-42 0.011
Data from Shibata et al. [62], Bell et al. [429] (see Appendix 2 of [146]) and Xie et al. [128]