There is evidence that plaques in the brain can be removed by reducing the ISF concentration of Aβ [428, 442]. However, it is likely that this only occurs if the Aβ concentration can be reduced to levels below those present before aggregate formation began [431]. This has been shown experimentally but it may not be achievable in practice without both inhibition of Aβ production (see e.g. [443]) and enhancement of Aβ clearance.