Web Resources
1000 Genomes, http://www.internationalgenome.org/
ClinVar, https://www.ncbi.nlm.nih.gov/clinvar/
DBNSFP, https://sites.google.com/site/jpopgen/dbNSFP
dbSNP, https://www.ncbi.nlm.nih.gov/projects/SNP/
Deafness Variation Database, http://deafnessvariationdatabase.com/
ExAC Browser, http://exac.broadinstitute.org/
GenBank, https://www.ncbi.nlm.nih.gov/genbank/
gnomAD Browser, http://gnomad.broadinstitute.org/
Hereditary Hearing Loss Homepage, http://hereditaryhearingloss.org
Human Gene Mutation Database (HGMD), https://www.qiagenbioinformatics.com/products/human-gene-mutation-database/
Kafeen, https://github.com/clcg/Kafeen
MutationTaster, http://www.mutationtaster.org/
NHLBI Exome Sequencing Project (ESP) Exome Variant Server, http://evs.gs.washington.edu/EVS/
OMIM, http://www.omim.org/
PolyPhen-2, http://genetics.bwh.harvard.edu/pph2/
RefSeq, https://www.ncbi.nlm.nih.gov/RefSeq
Ruby programming language, https://www.ruby-lang.org/
SIFT, http://sift.bii.a-star.edu.sg/

Supplemental Data
Document S1. Figures S1–S6
Data S1. Tables S1–S7
Document S2. Article plus Supplemental Data

Acknowledgments
The authors thank Julie S. Wertz and Andrea Hallier for help with bioinformatic troubleshooting. The authors are also grateful to all DVD users who have submitted data and provided feedback. This work was supported by NIDCD RO1s DC003544, DC002842, and DC012049 to R.J.H.S. Supplemental Data include six figures and seven tables and can be found with this article online at https://doi.org/10.1016/j.ajhg.2018.08.006.