This work was funded by the Medical Research Council (MR/M012212/1), Kidney Research UK (post-doctoral fellowship PDF_003_20151124 to S.A.R.), King Salman Center for Disability Research (F.S.A.), King Abdulaziz City for Science and Technology (13-BIO1113-20 to F.S.A.), Saudi Human Genome Program (F.S.A.), Northern Counties Kidney Research Fund (J.A.S. and E.M.), and Cancer Research UK (core funding award A19257 to Y.E., L.S., and S.I.).