↓Fas in human islets↓MiR-375 in human islets↓PBMC activation↓PBMC proliferation↓IL-2↓IFN-γ↓IL-2 receptor↑HGF↑IL-10↑VEGF↑PGE-2↑TGF-β↑Treg function↓Islet β-cells apoptosis↑Islet β-cells function against inflammatory cytokines↓Immune reaction against transplanted islets after humanization of mice