↑Nestin↑Pdx1 transcription factor↑Ngn3 transcription factor↑Pax4 transcription factor↑NeuroD1 transcription factor↑Nkx2.2 transcription factor↑Nkx6.1 transcription factor↑PCSK1 gene↑Insulin gene↑Glucagon gene↑PCSK1 gene↑PP gene