A comparison of the variant detection was performed on the basis of the 105 ACMG-assessed SNVs and indels that were detected by WGS and were within a gene sequenced by the TCP. 99/105 variants were called from TCP data with quality indicators sufficient to pass filters used for the WGS data. Five undetected variants—including one P/LP PMS2 variant (c.741−742insTGAAG [p.Pro247_Ser248fs] [Ensembl: ENST00000265849; GenBank: NM_000535.6]), where 58/202 (20.6%) reads contained the insertion—were indels for which IGV review showed a VAF below the threshold for filtering. One undetected variant in TMEM127 (MIM: 613403) (c.665C>T [p.Ala222Val] [Ensembl: ENST00000258439; GenBank: NM_017849.3]) was covered by only two reads.