All-but-One Conditional Analysis to Isolate Independent eQTL Signatures
(A) Hypothetical GWAS signature (top, green) at a given locus and an overlapping hypothetical eQTL signature (bottom, purple), which comprises two independent eQTL.
(B) Same hypothetical GWAS and eQTL signatures after the all-but-one conditional eQTL analysis isolating the primary (red) and secondary (blue) eQTL signatures. Before conditional analysis there is a lack of co-localization between the GWAS signature and eQTL signature. After all-but-one conditional analysis, there is evidence for co-localization between the conditional (secondary) eQTL and GWAS signatures.