Figure 2 Enrichments of Primary and Conditional eQTL in Active Regulatory Annotations
Plotted are enrichments (regression coefficient estimate ± 95% CI from logistic regression, y axes) of primary (x axis eQTL order = 1) and conditional (eQTL order = 2, ≥ 3) eQTL in functional annotations.
(A and B) Enrichment in brain (union of all individual brain regions) and brain-specific (present in brain but not in seven other non-brain tissues) active promoter (green) and enhancer (orange) ChromHMM states from the NIH Roadmap Epigenomics Project.
(C) Enrichment in neuronal nuclei (NeuN+) for active promoters (intersection of DLPFC H3K4me3 and H3K27ac ChIP-seq peaks, green) and enhancers (H3K27 peaks that do not overlap H3K4me3 peaks, orange).
(D) Enrichments in the same annotations, but for DLPFC non-neuronal nuclei (NeuN−).