Classical haplotypes in eastern Arabia tend to have the Arabian/Indian designation, whereas those in western Arabia tend to have the Benin designation.18, 21 The Arabian/Indian haplotype has been hypothesized to have originated in either east Saudi Arabia or India.5 Although our samples include only one predicted instance of the Arabian/Indian haplotype, the occurrence of this haplotype in the Luhya in Kenya and its clustering with the predominant haplotype found in Kenya and Uganda are consistent with the hypothesis that the Arabian/Indian haplotype originated in Africa and had an overseas migration route from eastern Africa to eastern Arabia and India.13, 19 In contrast, the absence of the Benin haplotype in the Luhya in Kenya and the Baganda in Uganda provides evidence against an overseas migration route from eastern Africa to western Arabia. Instead, the presence of the Benin haplotype in western Arabia is consistent with an African origin and an overland migration route through northeast Africa.33