We defined haplotypes centered on rs334 in the 504 continental Africans from the 1000 Genomes Project. We recorded pairwise linkage disequilibrium (LD) between rs334 and all phased, diallelic markers on chromosome 11 (Figure 2). The largest value of r2 with rs334 was 0.407. There was only one marker, rs149481026, with r2≥0.4. This one marker was more strongly associated with rs334 (V˜2=0.406) than the set of four RFLP-predicting markers was (Figure 1A).
Figure 2 Linkage Disequilibrium with rs334
We calculated pairwise r2 with rs334 across chromosome 11 among 504 continental Africans from the 1000 Genomes Project. We plotted r2 for all 4,024,958 phased diallelic markers.