To test for associations between FECD disease affection status and polymorphic markers, we built logistic regression models in the above described groups of affected subjects and control subjects. FECD diagnosis was the outcome and the number of alleles with 50 or more repeats was used as the independent variable. Three association models were built: the first model was run in both male and female participants and included adjustment for sex. The other two models were sex specific, restricted to strata of male and female participants only (therefore not adjusted for sex). All the models were tested for significance using the “glm” function from the R 3.4.1 statistical software base packages.