We acknowledge the patients, GPs, paediatricians and the nurse who participated in this study as well as the contribution of Jesús Almeda, Rosa Morros, Rosa Juvé, Pere Simonet, Laura Prats and Edurne Zabaleta in developing the project. We would also like to thank Francois Schellevis, Mike Pringle, Ellen Stobberingh, Herman Goossens and Gilles Hebbrecht who conducted and coordinated the APRES project and Samuel Coenen for his contribution to the protocol.