The commensal flora of community-dwelling persons is, therefore, becoming an important reservoir of resistant bacteria. Fighting antibiotic resistance starts with the restricted use of antibiotics, leading to less selection pressure on the bacterial flora circulating in the population, but also on the commensal flora in an individual. Knowledge of the local resistance rates of the most common organisms to antibiotics is crucial for better prescribing of antibiotics. In a recent paper from the APRES project, van Bijnen et al. observed that many guidelines for skin infections do not contain data on local resistance [29]. GPs should be informed of the resistance profiles of the most frequent organisms causing infectious disease for more prudent use of antibiotics.