Does SD influence rats' spatial memory and learning? Does SD have any effects on the volume of the mPFC and its ACC, PLC, and ILC? Does the number of neurons and glial cells in the mPFC change after SD? Do the dendrites' length and their spines' morphology (mushroom, thin, and stubby types) undergo any change after SD? Can CUR protect the alteration in spatial memory, learning and mPFC structure of the SD animals?