Despite the evident effects of SD on PFC function, it remains scantily understood how sleep loss affects the essential characteristics of neurons and/or glial cells in the prefrontal cortex. In general, it is assumed that SD raises oxidative stress in diverse brain regions, including the mPFC (Ramanathan et al., 2002[23]). Another mechanism could be clarified by the research by Jiang et al. (2006[11]) who reported that neuron apoptosis could be detected in sleep deprived-animals (Jiang et al., 2006[11]).