The diagnostic yield in our OGID series is higher than exome-sequencing studies in other phenotypes that include intellectual disability, which ranged from 13% to 35%.22, 52, 53, 54, 55, 56 The studies are not directly comparable, as most other exome studies included case subjects in which prior genetic testing was negative. Our study recruitment started prior to the discovery and clinical testing of most of the genes we report here, which allows us to provide a much better estimate of the overall contribution of rare gene mutations to this phenotype.