GESTALT GESTALT (27) is a workbench for genome annotation that combines automated and manual analysis with an emphasis on rich graphical display of the analysis results. GESTALT can execute a variety of external analysis programs (e.g. for gene recognition) as well as internal analyses (e.g. for compositional complexity analysis). The results are stored in an internal database and can later be retrieved and displayed. GESTALT analyses have been carried out on most T1D human candidate regions, and the results can be inspected on T1DBase. Several new genes were found through this analysis. For operational reasons, users are not allowed to run their own GESTALT analyses on our website, but can do so on the public GESTALT server at http://db.systemsbiology.net/gestalt/.