SAVI-1 and SAVI-2 are prospective, all-comers, multicentre registries conducted in 17 (SAVI-1) and 26 (SAVI-2) centres in Europe and Argentina, but predominantly in Germany. The study design and population of SAVI-1 has been described previously [6]. SAVI-2 has a similar design. Treatment and follow-up were according to the standard of care at the respective hospital. Clinical follow-up, including echocardiographic assessment, was scheduled at discharge or after 7 days, whichever was earlier; at 30 days, a telephone follow-up was conducted (for SAVI-1, clinical and echocardiographic follow-up was scheduled at 30 days). The last registry follow-up was at 12 months, including clinical and (voluntary) echocardiographic assessments. Each registry was scheduled to enrol 250 patients.