PMC:539297 / 247-479 JSONTXT

{"project":"craft-ca-core-dev","denotations":[{"id":"T65","span":{"begin":33,"end":37},"obj":"PR:000005591"},{"id":"T66","span":{"begin":70,"end":78},"obj":"PR:000005591"},{"id":"T67","span":{"begin":111,"end":124},"obj":"GO:0005739"},{"id":"T68","span":{"begin":111,"end":148},"obj":"PR:000022190"},{"id":"T69","span":{"begin":172,"end":175},"obj":"UBERON:0001017"},{"id":"T70","span":{"begin":172,"end":183},"obj":"CL:0000117"},{"id":"T71","span":{"begin":209,"end":213},"obj":"PR:000005591"}],"text":" most-commonly caused by a ~1 kb CLN3 mutation. The resulting loss of battenin activity leads to deposition of mitochondrial ATP synthase, subunit c and a specific loss of CNS neurons. We previously generated Cln3Δex7/8 knock-in mic"}

{"project":"craft-sa-dev","denotations":[{"id":"T205","span":{"begin":1,"end":5},"obj":"RBS"},{"id":"T206","span":{"begin":6,"end":14},"obj":"RB"},{"id":"T207","span":{"begin":5,"end":6},"obj":"HYPH"},{"id":"T208","span":{"begin":15,"end":21},"obj":"VBN"},{"id":"T209","span":{"begin":22,"end":24},"obj":"IN"},{"id":"T210","span":{"begin":25,"end":26},"obj":"DT"},{"id":"T211","span":{"begin":38,"end":46},"obj":"NN"},{"id":"T212","span":{"begin":27,"end":28},"obj":"SYM"},{"id":"T213","span":{"begin":28,"end":29},"obj":"CD"},{"id":"T214","span":{"begin":30,"end":32},"obj":"NN"},{"id":"T215","span":{"begin":33,"end":37},"obj":"NN"},{"id":"T216","span":{"begin":46,"end":47},"obj":"."},{"id":"T217","span":{"begin":47,"end":184},"obj":"sentence"},{"id":"T218","span":{"begin":48,"end":51},"obj":"DT"},{"id":"T219","span":{"begin":62,"end":66},"obj":"NN"},{"id":"T220","span":{"begin":52,"end":61},"obj":"JJ"},{"id":"T221","span":{"begin":88,"end":93},"obj":"VBZ"},{"id":"T222","span":{"begin":67,"end":69},"obj":"IN"},{"id":"T223","span":{"begin":70,"end":78},"obj":"NN"},{"id":"T224","span":{"begin":79,"end":87},"obj":"NN"},{"id":"T225","span":{"begin":94,"end":96},"obj":"IN"},{"id":"T226","span":{"begin":97,"end":107},"obj":"NN"},{"id":"T227","span":{"begin":108,"end":110},"obj":"IN"},{"id":"T228","span":{"begin":111,"end":124},"obj":"JJ"},{"id":"T229","span":{"begin":129,"end":137},"obj":"NN"},{"id":"T230","span":{"begin":125,"end":128},"obj":"NN"},{"id":"T231","span":{"begin":137,"end":139},"obj":","},{"id":"T232","span":{"begin":139,"end":146},"obj":"NN"},{"id":"T233","span":{"begin":147,"end":148},"obj":"NN"},{"id":"T234","span":{"begin":149,"end":152},"obj":"CC"},{"id":"T235","span":{"begin":153,"end":154},"obj":"DT"},{"id":"T236","span":{"begin":164,"end":168},"obj":"NN"},{"id":"T237","span":{"begin":155,"end":163},"obj":"JJ"},{"id":"T238","span":{"begin":169,"end":171},"obj":"IN"},{"id":"T239","span":{"begin":172,"end":175},"obj":"NN"},{"id":"T240","span":{"begin":176,"end":183},"obj":"NNS"},{"id":"T241","span":{"begin":183,"end":184},"obj":"."},{"id":"T243","span":{"begin":185,"end":187},"obj":"PRP"},{"id":"T244","span":{"begin":199,"end":208},"obj":"VBD"},{"id":"T245","span":{"begin":188,"end":198},"obj":"RB"},{"id":"T246","span":{"begin":209,"end":217},"obj":"NN"},{"id":"T248","span":{"begin":217,"end":218},"obj":"HYPH"},{"id":"T249","span":{"begin":218,"end":219},"obj":"CD"},{"id":"T250","span":{"begin":220,"end":225},"obj":"VB"},{"id":"T251","span":{"begin":225,"end":226},"obj":"HYPH"},{"id":"T252","span":{"begin":226,"end":228},"obj":"RP"}],"relations":[{"id":"R30","pred":"advmod","subj":"T205","obj":"T206"},{"id":"R32","pred":"punct","subj":"T207","obj":"T206"},{"id":"R34","pred":"agent","subj":"T209","obj":"T208"},{"id":"R35","pred":"det","subj":"T210","obj":"T211"},{"id":"R36","pred":"pobj","subj":"T211","obj":"T209"},{"id":"R37","pred":"punct","subj":"T212","obj":"T213"},{"id":"R38","pred":"nummod","subj":"T213","obj":"T214"},{"id":"R39","pred":"compound","subj":"T214","obj":"T211"},{"id":"R40","pred":"compound","subj":"T215","obj":"T211"},{"id":"R42","pred":"det","subj":"T218","obj":"T219"},{"id":"R44","pred":"amod","subj":"T220","obj":"T219"},{"id":"R45","pred":"prep","subj":"T222","obj":"T219"},{"id":"R46","pred":"compound","subj":"T223","obj":"T224"},{"id":"R47","pred":"pobj","subj":"T224","obj":"T222"},{"id":"R48","pred":"prep","subj":"T225","obj":"T221"},{"id":"R49","pred":"pobj","subj":"T226","obj":"T225"},{"id":"R50","pred":"prep","subj":"T227","obj":"T226"},{"id":"R51","pred":"amod","subj":"T228","obj":"T229"},{"id":"R53","pred":"compound","subj":"T230","obj":"T229"},{"id":"R54","pred":"punct","subj":"T231","obj":"T229"},{"id":"R55","pred":"compound","subj":"T232","obj":"T233"},{"id":"R56","pred":"npadvmod","subj":"T233","obj":"T229"},{"id":"R57","pred":"cc","subj":"T234","obj":"T226"},{"id":"R58","pred":"det","subj":"T235","obj":"T236"},{"id":"R60","pred":"amod","subj":"T237","obj":"T236"},{"id":"R61","pred":"prep","subj":"T238","obj":"T236"},{"id":"R62","pred":"compound","subj":"T239","obj":"T240"},{"id":"R63","pred":"pobj","subj":"T240","obj":"T238"},{"id":"R64","pred":"punct","subj":"T241","obj":"T221"},{"id":"R65","pred":"nsubj","subj":"T243","obj":"T244"},{"id":"R66","pred":"advmod","subj":"T245","obj":"T244"},{"id":"R69","pred":"punct","subj":"T248","obj":"T246"},{"id":"R70","pred":"nummod","subj":"T249","obj":"T246"},{"id":"R72","pred":"punct","subj":"T251","obj":"T250"},{"id":"R73","pred":"prt","subj":"T252","obj":"T250"},{"id":"R31","pred":"advmod","subj":"T206","obj":"T208"},{"id":"R43","pred":"nsubj","subj":"T219","obj":"T221"},{"id":"R52","pred":"pobj","subj":"T229","obj":"T227"},{"id":"R59","pred":"conj","subj":"T236","obj":"T226"}],"text":" most-commonly caused by a ~1 kb CLN3 mutation. The resulting loss of battenin activity leads to deposition of mitochondrial ATP synthase, subunit c and a specific loss of CNS neurons. We previously generated Cln3Δex7/8 knock-in mic"}

{"project":"craft-ca-core-ex-dev","denotations":[{"id":"T111","span":{"begin":31,"end":32},"obj":"CHEBI_SO_EXT:base"},{"id":"T112","span":{"begin":33,"end":37},"obj":"PR_EXT:000005591"},{"id":"T113","span":{"begin":38,"end":46},"obj":"SO_EXT:sequence_alteration_entity_or_process"},{"id":"T114","span":{"begin":70,"end":78},"obj":"PR_EXT:000005591"},{"id":"T115","span":{"begin":111,"end":124},"obj":"GO:0005739"},{"id":"T116","span":{"begin":111,"end":148},"obj":"PR_EXT:000022190"},{"id":"T117","span":{"begin":125,"end":128},"obj":"CHEBI_EXT:ATP"},{"id":"T118","span":{"begin":172,"end":175},"obj":"UBERON:0001017"},{"id":"T119","span":{"begin":172,"end":183},"obj":"CL:0000117"},{"id":"T120","span":{"begin":209,"end":213},"obj":"PR_EXT:000005591"}],"text":" most-commonly caused by a ~1 kb CLN3 mutation. The resulting loss of battenin activity leads to deposition of mitochondrial ATP synthase, subunit c and a specific loss of CNS neurons. We previously generated Cln3Δex7/8 knock-in mic"}