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PMC:539297 / 23305-24394 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T4217 659-668 PR:000022190 denotes subunit c
T4218 683-696 GO:0005739 denotes Mitochondrial
T4219 769-775 NCBITaxon:33208 denotes animal
T4220 832-841 GO:0006914 denotes autophagy
T4221 845-854 GO:0005764 denotes lysosomal
T4222 912-920 PR:000005591 denotes battenin
T4223 943-956 GO:0005739 denotes mitochondrial
T4224 998-1011 GO:0005739 denotes mitochondrial
T4225 1038-1047 _FRAGMENT denotes transport
T4226 1063-1065 _FRAGMENT denotes of
T4227 1080-1088 GO:0015031 denotes proteins
T4228 1052-1088 GO:0034982 denotes processing of mitochondrial proteins
T4229 1066-1079 GO:0005739 denotes mitochondrial
T4198 0-8 _FRAGMENT denotes Aging of
T4199 33-38 GO:0007569 denotes cells
T4200 20-22 UBERON:0002037 denotes Cb
T4201 22-26 PR:000005591 denotes Cln3
T4202 102-111 PR:000022190 denotes subunit c
T4203 130-148 GO:0043227 denotes membrane organelle
T4204 169-178 PR:000022190 denotes subunit c
T4205 206-208 UBERON:0002037 denotes Cb
T4206 208-212 PR:000005591 denotes Cln3
T4207 258-263 GO:0007568 denotes aging
T4208 279-288 GO:0005764 denotes Lysosomal
T4209 293-302 GO:0005768 denotes endosomal
T4210 342-354 GO:0005739 denotes mitochondria
T4211 437-439 UBERON:0002037 denotes Cb
T4212 439-443 PR:000005591 denotes Cln3
T4213 490-498 GO:0016020 denotes membrane
T4214 490-510 GO:0055085 denotes membrane trafficking
T4215 548-557 PR:000022190 denotes subunit c
T4216 588-596 GO:0005764 denotes lysosome
R2369 T4199 T4198 _lexicallyChainedTo cells,Aging of
R2370 T4226 T4225 _lexicallyChainedTo of,transport
R2371 T4227 T4226 _lexicallyChainedTo proteins,of

craft-sa-dev

Id Subject Object Predicate Lexical cue
T4668 0-5 NN denotes Aging
T4669 53-55 VBZ denotes is
T4670 6-8 IN denotes of
T4671 9-19 JJ denotes homozygous
T4672 33-38 NNS denotes cells
T4673 20-30 NN denotes CbCln3Δex7
T4674 30-31 HYPH denotes /
T4675 31-32 CD denotes 8
T4676 39-41 IN denotes at
T4677 42-52 NN denotes confluency
T4678 56-65 JJ denotes necessary
T4679 66-68 TO denotes to
T4680 69-75 VB denotes induce
T4681 76-89 RB denotes significantly
T4682 90-101 VBN denotes accumulated
T4683 112-119 NN denotes protein
T4684 102-109 NN denotes subunit
T4685 110-111 NN denotes c
T4686 119-120 . denotes .
T4687 120-278 sentence denotes However, membrane organelle disruptions precede subunit c accumulation in homozygous CbCln3Δex7/8 cells, since they are observed without aging at confluency.
T4688 121-128 RB denotes However
T4689 161-168 VBP denotes precede
T4690 128-130 , denotes ,
T4691 130-138 NN denotes membrane
T4692 139-148 NN denotes organelle
T4693 149-160 NNS denotes disruptions
T4694 169-176 NN denotes subunit
T4695 177-178 NN denotes c
T4696 179-191 NN denotes accumulation
T4697 192-194 IN denotes in
T4698 195-205 JJ denotes homozygous
T4699 219-224 NNS denotes cells
T4700 206-216 NN denotes CbCln3Δex7
T4701 216-217 HYPH denotes /
T4702 217-218 CD denotes 8
T4703 224-226 , denotes ,
T4704 226-231 IN denotes since
T4705 241-249 VBN denotes observed
T4706 232-236 PRP denotes they
T4707 237-240 VBP denotes are
T4708 250-257 IN denotes without
T4709 258-263 VBG denotes aging
T4710 264-266 IN denotes at
T4711 267-277 NN denotes confluency
T4712 277-278 . denotes .
T4713 278-459 sentence denotes Lysosomal and endosomal size and distribution are altered, and mitochondria are abnormally elongated and functionally compromised in sub-confluent homozygous CbCln3Δex7/8 cultures.
T4714 279-288 JJ denotes Lysosomal
T4715 303-307 NN denotes size
T4716 289-292 CC denotes and
T4717 293-302 JJ denotes endosomal
T4718 329-336 VBN denotes altered
T4719 308-311 CC denotes and
T4720 312-324 NN denotes distribution
T4721 325-328 VBP denotes are
T4722 336-338 , denotes ,
T4723 338-341 CC denotes and
T4724 342-354 NNS denotes mitochondria
T4725 355-358 VBP denotes are
T4726 359-369 RB denotes abnormally
T4727 370-379 VBN denotes elongated
T4728 380-383 CC denotes and
T4729 384-396 RB denotes functionally
T4730 397-408 VBN denotes compromised
T4731 409-411 IN denotes in
T4732 412-425 JJ denotes sub-confluent
T4733 450-458 NNS denotes cultures
T4734 426-436 JJ denotes homozygous
T4735 437-447 NN denotes CbCln3Δex7
T4736 447-448 HYPH denotes /
T4737 448-449 CD denotes 8
T4738 458-459 . denotes .
T4739 459-682 sentence denotes These observations argue that membrane trafficking defects do not result from excessive subunit c accumulation compromising the lysosome, but rather are early events in the disease process preceding subunit c accumulation.
T4740 460-465 DT denotes These
T4741 466-478 NNS denotes observations
T4742 479-484 VBP denotes argue
T4743 485-489 IN denotes that
T4744 526-532 VB denotes result
T4745 490-498 NN denotes membrane
T4746 499-510 NN denotes trafficking
T4747 511-518 NNS denotes defects
T4748 519-521 VBP denotes do
T4749 522-525 RB denotes not
T4750 533-537 IN denotes from
T4751 538-547 JJ denotes excessive
T4752 558-570 NN denotes accumulation
T4753 548-555 NN denotes subunit
T4754 556-557 NN denotes c
T4755 571-583 VBG denotes compromising
T4756 584-587 DT denotes the
T4757 588-596 NN denotes lysosome
T4758 596-598 , denotes ,
T4759 598-601 CC denotes but
T4760 602-608 RB denotes rather
T4761 609-612 VBP denotes are
T4762 613-618 JJ denotes early
T4763 619-625 NNS denotes events
T4764 626-628 IN denotes in
T4765 629-632 DT denotes the
T4766 641-648 NN denotes process
T4767 633-640 NN denotes disease
T4768 649-658 VBG denotes preceding
T4769 659-666 NN denotes subunit
T4770 667-668 NN denotes c
T4771 669-681 NN denotes accumulation
T4772 681-682 . denotes .
T4773 682-877 sentence denotes Mitochondrial abnormalities, which have also been reported in JNCL patients and other animal models [21-23], may result from ineffective turnover by autophagy, a lysosomal-targeted pathway [24].
T4774 683-696 JJ denotes Mitochondrial
T4775 697-710 NNS denotes abnormalities
T4776 796-802 VB denotes result
T4777 710-712 , denotes ,
T4778 712-717 WDT denotes which
T4779 733-741 VBN denotes reported
T4780 718-722 VBP denotes have
T4781 723-727 RB denotes also
T4782 728-732 VBN denotes been
T4783 742-744 IN denotes in
T4784 745-749 NN denotes JNCL
T4785 750-758 NNS denotes patients
T4786 759-762 CC denotes and
T4787 763-768 JJ denotes other
T4788 776-782 NNS denotes models
T4789 769-775 NN denotes animal
T4790 783-784 -LRB- denotes [
T4791 784-786 CD denotes 21
T4792 786-787 SYM denotes -
T4793 787-789 CD denotes 23
T4794 789-790 -RRB- denotes ]
T4795 790-792 , denotes ,
T4796 792-795 MD denotes may
T4797 803-807 IN denotes from
T4798 808-819 JJ denotes ineffective
T4799 820-828 NN denotes turnover
T4800 829-831 IN denotes by
T4801 832-841 NN denotes autophagy
T4802 841-843 , denotes ,
T4803 843-844 DT denotes a
T4804 864-871 NN denotes pathway
T4805 845-854 JJ denotes lysosomal
T4806 855-863 VBN denotes targeted
T4807 854-855 HYPH denotes -
T4808 872-873 -LRB- denotes [
T4809 873-875 CD denotes 24
T4810 875-876 -RRB- denotes ]
T4811 876-877 . denotes .
T4812 877-1089 sentence denotes Alternatively, or simultaneously, battenin deficiency may impact mitochondrial function upstream of turnover, affecting mitochondrial biogenesis and/or altered transport and processing of mitochondrial proteins.
T4813 878-891 RB denotes Alternatively
T4814 936-942 VB denotes impact
T4815 891-893 , denotes ,
T4816 893-895 CC denotes or
T4817 896-910 RB denotes simultaneously
T4818 910-912 , denotes ,
T4819 912-920 NN denotes battenin
T4820 921-931 NN denotes deficiency
T4821 932-935 MD denotes may
T4822 943-956 JJ denotes mitochondrial
T4823 957-965 NN denotes function
T4824 966-974 RB denotes upstream
T4825 975-977 IN denotes of
T4826 978-986 NN denotes turnover
T4827 986-988 , denotes ,
T4828 988-997 VBG denotes affecting
T4829 998-1011 JJ denotes mitochondrial
T4830 1012-1022 NN denotes biogenesis
T4831 1023-1026 CC denotes and
T4832 1026-1027 HYPH denotes /
T4833 1027-1029 CC denotes or
T4834 1030-1037 VBN denotes altered
T4835 1038-1047 NN denotes transport
T4836 1048-1051 CC denotes and
T4837 1052-1062 NN denotes processing
T4838 1063-1065 IN denotes of
T4839 1066-1079 JJ denotes mitochondrial
T4840 1080-1088 NN denotes proteins
T4841 1088-1089 . denotes .
R2617 T4668 T4669 nsubj Aging,is
R2618 T4670 T4668 prep of,Aging
R2619 T4671 T4672 amod homozygous,cells
R2620 T4672 T4670 pobj cells,of
R2621 T4673 T4672 nmod CbCln3Δex7,cells
R2622 T4674 T4673 punct /,CbCln3Δex7
R2623 T4675 T4673 nummod 8,CbCln3Δex7
R2624 T4676 T4668 prep at,Aging
R2625 T4677 T4676 pobj confluency,at
R2626 T4678 T4669 acomp necessary,is
R2627 T4679 T4680 aux to,induce
R2628 T4680 T4678 xcomp induce,necessary
R2629 T4681 T4682 advmod significantly,accumulated
R2630 T4682 T4683 amod accumulated,protein
R2631 T4683 T4680 dobj protein,induce
R2632 T4684 T4685 compound subunit,c
R2633 T4685 T4683 compound c,protein
R2634 T4686 T4669 punct .,is
R2635 T4688 T4689 advmod However,precede
R2636 T4690 T4689 punct ", ",precede
R2637 T4691 T4692 compound membrane,organelle
R2638 T4692 T4693 compound organelle,disruptions
R2639 T4693 T4689 nsubj disruptions,precede
R2640 T4694 T4695 compound subunit,c
R2641 T4695 T4696 compound c,accumulation
R2642 T4696 T4689 dobj accumulation,precede
R2643 T4697 T4689 prep in,precede
R2644 T4698 T4699 amod homozygous,cells
R2645 T4699 T4697 pobj cells,in
R2646 T4700 T4699 nmod CbCln3Δex7,cells
R2647 T4701 T4700 punct /,CbCln3Δex7
R2648 T4702 T4700 nummod 8,CbCln3Δex7
R2649 T4703 T4689 punct ", ",precede
R2650 T4704 T4705 mark since,observed
R2651 T4705 T4689 advcl observed,precede
R2652 T4706 T4705 nsubjpass they,observed
R2653 T4707 T4705 auxpass are,observed
R2654 T4708 T4705 prep without,observed
R2655 T4709 T4708 pobj aging,without
R2656 T4710 T4705 prep at,observed
R2657 T4711 T4710 pobj confluency,at
R2658 T4712 T4689 punct .,precede
R2659 T4714 T4715 amod Lysosomal,size
R2660 T4715 T4718 nsubjpass size,altered
R2661 T4716 T4714 cc and,Lysosomal
R2662 T4717 T4714 conj endosomal,Lysosomal
R2663 T4719 T4715 cc and,size
R2664 T4720 T4715 conj distribution,size
R2665 T4721 T4718 auxpass are,altered
R2666 T4722 T4718 punct ", ",altered
R2667 T4723 T4718 cc and,altered
R2668 T4724 T4725 nsubj mitochondria,are
R2669 T4725 T4718 conj are,altered
R2670 T4726 T4727 advmod abnormally,elongated
R2671 T4727 T4725 acomp elongated,are
R2672 T4728 T4727 cc and,elongated
R2673 T4729 T4730 advmod functionally,compromised
R2674 T4730 T4727 conj compromised,elongated
R2675 T4731 T4725 prep in,are
R2676 T4732 T4733 amod sub-confluent,cultures
R2677 T4733 T4731 pobj cultures,in
R2678 T4734 T4733 amod homozygous,cultures
R2679 T4735 T4733 nmod CbCln3Δex7,cultures
R2680 T4736 T4735 punct /,CbCln3Δex7
R2681 T4737 T4735 nummod 8,CbCln3Δex7
R2682 T4738 T4725 punct .,are
R2683 T4740 T4741 det These,observations
R2684 T4741 T4742 nsubj observations,argue
R2685 T4743 T4744 mark that,result
R2686 T4744 T4742 ccomp result,argue
R2687 T4745 T4746 compound membrane,trafficking
R2688 T4746 T4747 compound trafficking,defects
R2689 T4747 T4744 nsubj defects,result
R2690 T4748 T4744 aux do,result
R2691 T4749 T4744 neg not,result
R2692 T4750 T4744 prep from,result
R2693 T4751 T4752 amod excessive,accumulation
R2694 T4752 T4755 nsubj accumulation,compromising
R2695 T4753 T4754 compound subunit,c
R2696 T4754 T4752 compound c,accumulation
R2697 T4755 T4750 pcomp compromising,from
R2698 T4756 T4757 det the,lysosome
R2699 T4757 T4755 dobj lysosome,compromising
R2700 T4758 T4744 punct ", ",result
R2701 T4759 T4744 cc but,result
R2702 T4760 T4759 advmod rather,but
R2703 T4761 T4744 conj are,result
R2704 T4762 T4763 amod early,events
R2705 T4763 T4761 attr events,are
R2706 T4764 T4763 prep in,events
R2707 T4765 T4766 det the,process
R2708 T4766 T4764 pobj process,in
R2709 T4767 T4766 compound disease,process
R2710 T4768 T4763 acl preceding,events
R2711 T4769 T4770 compound subunit,c
R2712 T4770 T4771 compound c,accumulation
R2713 T4771 T4768 dobj accumulation,preceding
R2714 T4772 T4742 punct .,argue
R2715 T4774 T4775 amod Mitochondrial,abnormalities
R2716 T4775 T4776 nsubj abnormalities,result
R2717 T4777 T4775 punct ", ",abnormalities
R2718 T4778 T4779 dep which,reported
R2719 T4779 T4775 relcl reported,abnormalities
R2720 T4780 T4779 aux have,reported
R2721 T4781 T4779 advmod also,reported
R2722 T4782 T4779 auxpass been,reported
R2723 T4783 T4779 prep in,reported
R2724 T4784 T4785 compound JNCL,patients
R2725 T4785 T4783 pobj patients,in
R2726 T4786 T4785 cc and,patients
R2727 T4787 T4788 amod other,models
R2728 T4788 T4785 conj models,patients
R2729 T4789 T4788 compound animal,models
R2730 T4790 T4791 punct [,21
R2731 T4791 T4779 parataxis 21,reported
R2732 T4792 T4793 punct -,23
R2733 T4793 T4791 prep 23,21
R2734 T4794 T4791 punct ],21
R2735 T4795 T4776 punct ", ",result
R2736 T4796 T4776 aux may,result
R2737 T4797 T4776 prep from,result
R2738 T4798 T4799 amod ineffective,turnover
R2739 T4799 T4797 pobj turnover,from
R2740 T4800 T4799 prep by,turnover
R2741 T4801 T4800 pobj autophagy,by
R2742 T4802 T4801 punct ", ",autophagy
R2743 T4803 T4804 det a,pathway
R2744 T4804 T4801 appos pathway,autophagy
R2745 T4805 T4806 amod lysosomal,targeted
R2746 T4806 T4804 amod targeted,pathway
R2747 T4807 T4806 punct -,targeted
R2748 T4808 T4809 punct [,24
R2749 T4809 T4776 parataxis 24,result
R2750 T4810 T4809 punct ],24
R2751 T4811 T4776 punct .,result
R2752 T4813 T4814 advmod Alternatively,impact
R2753 T4815 T4813 punct ", ",Alternatively
R2754 T4816 T4813 cc or,Alternatively
R2755 T4817 T4813 conj simultaneously,Alternatively
R2756 T4818 T4814 punct ", ",impact
R2757 T4819 T4820 compound battenin,deficiency
R2758 T4820 T4814 nsubj deficiency,impact
R2759 T4821 T4814 aux may,impact
R2760 T4822 T4823 amod mitochondrial,function
R2761 T4823 T4814 dobj function,impact
R2762 T4824 T4823 advmod upstream,function
R2763 T4825 T4824 prep of,upstream
R2764 T4826 T4825 pobj turnover,of
R2765 T4827 T4814 punct ", ",impact
R2766 T4828 T4814 advcl affecting,impact
R2767 T4829 T4830 amod mitochondrial,biogenesis
R2768 T4830 T4828 dobj biogenesis,affecting
R2769 T4831 T4830 cc and,biogenesis
R2770 T4832 T4831 punct /,and
R2771 T4833 T4831 cc or,and
R2772 T4834 T4835 amod altered,transport
R2773 T4835 T4830 conj transport,biogenesis
R2774 T4836 T4835 cc and,transport
R2775 T4837 T4835 conj processing,transport
R2776 T4838 T4835 prep of,transport
R2777 T4839 T4840 amod mitochondrial,proteins
R2778 T4840 T4838 pobj proteins,of
R2779 T4841 T4814 punct .,impact

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T4327 0-8 _FRAGMENT denotes Aging of
T4328 33-38 GO:0007569 denotes cells
T4329 20-22 UBERON:0002037 denotes Cb
T4330 22-26 PR_EXT:000005591 denotes Cln3
T4331 33-38 CL_GO_EXT:cell denotes cells
T4332 102-111 PR_EXT:000022190 denotes subunit c
T4333 112-119 CHEBI_PR_EXT:protein denotes protein
T4334 130-148 GO:0043227 denotes membrane organelle
T4335 169-178 PR_EXT:000022190 denotes subunit c
T4336 206-208 UBERON:0002037 denotes Cb
T4337 208-212 PR_EXT:000005591 denotes Cln3
T4338 219-224 CL_GO_EXT:cell denotes cells
T4339 258-263 GO:0007568 denotes aging
T4340 279-288 GO:0005764 denotes Lysosomal
T4341 293-302 GO:0005768 denotes endosomal
T4342 342-354 GO:0005739 denotes mitochondria
T4343 437-439 UBERON:0002037 denotes Cb
T4344 439-443 PR_EXT:000005591 denotes Cln3
T4345 490-498 GO:0016020 denotes membrane
T4346 490-510 GO:0055085 denotes membrane trafficking
T4347 548-557 PR_EXT:000022190 denotes subunit c
T4348 588-596 GO:0005764 denotes lysosome
T4349 659-668 PR_EXT:000022190 denotes subunit c
T4350 683-696 GO:0005739 denotes Mitochondrial
T4351 769-775 NCBITaxon:33208 denotes animal
T4352 832-841 GO:0006914 denotes autophagy
T4353 845-854 GO:0005764 denotes lysosomal
T4354 912-920 PR_EXT:000005591 denotes battenin
T4355 943-956 GO:0005739 denotes mitochondrial
T4356 998-1011 GO:0005739 denotes mitochondrial
T4357 1012-1022 GO_EXT:biogenesis_or_biosynthesis denotes biogenesis
T4358 1038-1047 _FRAGMENT denotes transport
T4359 1063-1065 _FRAGMENT denotes of
T4360 1080-1088 GO:0015031 denotes proteins
T4361 1052-1062 SO_EXT:sequence_alteration_process denotes processing
T4362 1052-1088 GO:0034982 denotes processing of mitochondrial proteins
T4363 1066-1079 GO:0005739 denotes mitochondrial
T4364 1080-1088 CHEBI_PR_EXT:protein denotes proteins
R2377 T4328 T4327 _lexicallyChainedTo cells,Aging of
R2378 T4359 T4358 _lexicallyChainedTo of,transport
R2379 T4360 T4359 _lexicallyChainedTo proteins,of

2_test

Id Subject Object Predicate Lexical cue
15588329-7668331-12950155 784-786 7668331 denotes 21
15588329-10191128-12950155 784-786 10191128 denotes 21
15588329-11588986-12950155 784-786 11588986 denotes 21
15588329-11099404-12950156 873-875 11099404 denotes 24