Our results are particularly interesting in light of the recent implication that GSK-3β controls Snail's stability and subcellular localization [50]. Since Wnts are known to deactivate GSK-3β, Wnt and TGF-β2 signaling may contribute to Snail's transient induction and accumulation. Moreover, since inhibition of GSK-3β results in Snail upregulation and E-cadherin downregulation, Snail and GSK-3β may function at a crossroads in controlling hair bud development.