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PMC:539061 / 4409-6391 JSONTXT

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craft-ca-core-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T632 99-109 UBERON:0000483 denotes epithelial
T633 114-125 UBERON:0003104 denotes mesenchymal
T634 148-151 PR:000000034 denotes BMP
T635 170-176 PR:000000021 denotes noggin
T636 208-234 PR:000009751 denotes lymphoid enhancer factor-1
T637 217-225 SO:0000165 denotes enhancer
T638 235-244 PR:000002198 denotes β-catenin
T639 246-251 PR:000009751 denotes LEF-1
T640 252-261 PR:000002198 denotes β-catenin
T641 272-276 SO:0000704 denotes gene
T642 302-318 UBERON:0011817 denotes follicle placode
T643 445-449 SO:0000704 denotes gene
T644 459-469 PR:000001447 denotes E-cadherin
T645 488-498 UBERON:0000483 denotes epithelial
T646 499-507 PR:000001327 denotes cadherin
T647 528-536 GO:0016020 denotes membrane
T648 545-577 GO:0005913 denotes intercellular adherens junctions
T649 579-582 GO:0005912 denotes AJs
T650 622-632 PR:000001447 denotes E-cadherin
T651 663-668 NCBITaxon:10088 denotes mouse
T652 675-688 UBERON:0002073 denotes hair follicle
T653 675-702 GO:0031069 denotes hair follicle morphogenesis
T654 731-741 PR:000001447 denotes E-cadherin
T655 781-790 GO:0065007 denotes governing
T656 835-848 GO:0009653 denotes morphogenesis
T657 859-864 PR:000009751 denotes LEF-1
T658 866-876 PR:000001447 denotes E-cadherin
T659 891-900 PR:000002198 denotes β-catenin
T660 942-952 PR:000001447 denotes E-cadherin
T661 953-962 PR:000002198 denotes β-catenin
T662 963-972 GO:0032991 denotes complexes
T663 1033-1053 GO:0030041 denotes actin polymerization
T664 1039-1053 MOP:0000629 denotes polymerization
T665 1094-1097 GO:0005912 denotes AJs
T666 1116-1128 GO:0005856 denotes cytoskeleton
T667 1139-1155 UBERON:0010136 denotes epithelial sheet
T668 1203-1208 PR:P20154 denotes Lin-1
T669 1210-1215 PR:000009116 denotes Isl-1
T670 1217-1222 PR:P09088 denotes Mec-3
T671 1237-1242 PR:000009231 denotes Ajuba
T672 1260-1265 PR:000018242 denotes zyxin
T673 1366-1373 CHEBI:52290 denotes mitogen
T674 1443-1446 GO:0005912 denotes AJs
T675 1483-1495 GO:0005856 denotes cytoskeletal
T676 1521-1528 GO:0005634 denotes nuclear
T677 1533-1544 GO:0005737 denotes cytoplasmic
T678 1606-1616 PR:000001447 denotes E-cadherin
T679 1760-1769 GO:0065007 denotes governing
T680 1770-1780 PR:000001447 denotes E-cadherin
T681 1781-1789 SO:0000167 denotes promoter
T682 1848-1853 PR:000009751 denotes LEF-1
T683 1854-1863 PR:000002198 denotes β-catenin
T684 1864-1876 SO:0000409 denotes binding site
T685 1905-1910 PR:000015308 denotes Snail
T686 1911-1915 PR:000015309 denotes Slug

2_test

Id Subject Object Predicate Lexical cue
15630473-12646922-84810237 320-321 12646922 denotes 4
15630473-12600316-84810238 585-586 12600316 denotes 5
15630473-12646922-84810239 850-851 12646922 denotes 4
15630473-9722621-84810240 1157-1158 9722621 denotes 6
15630473-10660044-84810241 1159-1160 10660044 denotes 7
15630473-12361600-84810242 1161-1162 12361600 denotes 8
15630473-10330178-84810243 1415-1416 10330178 denotes 9
15630473-12417594-84810244 1417-1419 12417594 denotes 10
15630473-11944044-84810245 1698-1700 11944044 denotes 11
15630473-10655587-84810246 1974-1976 10655587 denotes 12
15630473-10655586-84810247 1977-1979 10655586 denotes 13
15630473-12508111-84810248 1980-1982 12508111 denotes 14
T8676 320-321 12646922 denotes 4
T8006 585-586 12600316 denotes 5
T43029 850-851 12646922 denotes 4
T83519 1157-1158 9722621 denotes 6
T99899 1159-1160 10660044 denotes 7
T86430 1161-1162 12361600 denotes 8
T24011 1415-1416 10330178 denotes 9
T57385 1417-1419 12417594 denotes 10
T38439 1698-1700 11944044 denotes 11
T86626 1974-1976 10655587 denotes 12
T40333 1977-1979 10655586 denotes 13
T36104 1980-1982 12508111 denotes 14

craft-ca-core-ex-dev

Below, discontinuous spans are shown in the chain model. You can change it to the bag model.

Id Subject Object Predicate Lexical cue
T851 44-52 UBERON_EXT:follicle denotes follicle
T852 99-109 UBERON:0000483 denotes epithelial
T853 114-125 UBERON:0003104 denotes mesenchymal
T854 148-151 PR_EXT:000000034 denotes BMP
T855 170-176 PR_EXT:000000021 denotes noggin
T856 208-216 CL_UBERON_EXT:lymphocyte_or_lymphoid_progenitor_or_system_or_tissue denotes lymphoid
T857 208-234 PR_EXT:000009751 denotes lymphoid enhancer factor-1
T858 217-225 SO_EXT:0000165 denotes enhancer
T859 235-244 PR_EXT:000002198 denotes β-catenin
T860 246-251 PR_EXT:000009751 denotes LEF-1
T861 252-261 PR_EXT:000002198 denotes β-catenin
T862 272-276 SO_EXT:0000704 denotes gene
T863 277-290 GO_EXT:transcription denotes transcription
T864 302-318 UBERON:0011817 denotes follicle placode
T865 395-413 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling pathways
T866 422-437 GO_EXT:negative_regulation denotes down-regulation
T867 445-449 SO_EXT:0000704 denotes gene
T868 450-458 SO_EXT:sequence_coding_function denotes encoding
T869 459-469 PR_EXT:000001447 denotes E-cadherin
T870 488-498 UBERON:0000483 denotes epithelial
T871 499-507 PR_EXT:000001327 denotes cadherin
T872 528-536 GO:0016020 denotes membrane
T873 545-577 GO:0005913 denotes intercellular adherens junctions
T874 550-558 CL_GO_EXT:cell denotes cellular
T875 579-582 GO:0005912 denotes AJs
T876 622-632 PR_EXT:000001447 denotes E-cadherin
T877 636-650 SO_EXT:transgenic_entity denotes transgenically
T878 663-668 NCBITaxon:10088 denotes mouse
T879 669-673 UBERON_EXT:zone_of_skin_or_skin_of_body denotes skin
T880 675-688 UBERON:0002073 denotes hair follicle
T881 675-702 GO:0031069 denotes hair follicle morphogenesis
T882 731-741 PR_EXT:000001447 denotes E-cadherin
T883 742-757 GO_EXT:negative_regulation denotes down-regulation
T884 781-790 GO:0065007 denotes governing
T885 795-803 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T886 835-848 GO:0009653 denotes morphogenesis
T887 859-864 PR_EXT:000009751 denotes LEF-1
T888 866-876 PR_EXT:000001447 denotes E-cadherin
T889 882-887 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T890 891-900 PR_EXT:000002198 denotes β-catenin
T891 914-918 CL_GO_EXT:cell denotes cell
T892 919-923 CL_GO_EXT:cell denotes cell
T893 942-952 PR_EXT:000001447 denotes E-cadherin
T894 953-962 PR_EXT:000002198 denotes β-catenin
T895 963-972 GO:0032991 denotes complexes
T896 973-980 GO_EXT:biological_recruitment denotes recruit
T897 981-990 PR_EXT:alpha_catenin denotes α-catenin
T898 1033-1053 GO:0030041 denotes actin polymerization
T899 1039-1053 MOP:0000629 denotes polymerization
T900 1094-1097 GO:0005912 denotes AJs
T901 1116-1128 GO:0005856 denotes cytoskeleton
T902 1139-1155 UBERON:0010136 denotes epithelial sheet
T903 1165-1174 PR_EXT:alpha_catenin denotes α-Catenin
T904 1180-1185 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binds
T905 1203-1208 PR_EXT:P20154 denotes Lin-1
T906 1210-1215 PR_EXT:000009116 denotes Isl-1
T907 1217-1222 PR_EXT:P09088 denotes Mec-3
T908 1229-1236 CHEBI_PR_EXT:protein denotes protein
T909 1237-1242 PR_EXT:000009231 denotes Ajuba
T910 1260-1265 PR_EXT:000018242 denotes zyxin
T911 1276-1284 CHEBI_PR_EXT:protein denotes proteins
T912 1328-1336 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T913 1366-1373 CHEBI_EXT:52290 denotes mitogen
T914 1366-1398 GO_PR_EXT:MAP_kinase denotes mitogen-activated protein kinase
T915 1384-1391 CHEBI_PR_EXT:protein denotes protein
T916 1400-1404 GO_PR_EXT:MAP_kinase denotes MAPK
T917 1443-1446 GO:0005912 denotes AJs
T918 1469-1477 GO_PATO_EXT:biological_adhesion_entity_or_process denotes adhesion
T919 1483-1495 GO:0005856 denotes cytoskeletal
T920 1521-1528 GO:0005634 denotes nuclear
T921 1533-1544 GO:0005737 denotes cytoplasmic
T922 1545-1554 GO_EXT:cell_communication_or_signaling_or_signal_transduction denotes signaling
T923 1606-1616 PR_EXT:000001447 denotes E-cadherin
T924 1760-1769 GO:0065007 denotes governing
T925 1770-1780 PR_EXT:000001447 denotes E-cadherin
T926 1781-1789 SO_EXT:0000167 denotes promoter
T927 1848-1853 PR_EXT:000009751 denotes LEF-1
T928 1854-1863 PR_EXT:000002198 denotes β-catenin
T929 1864-1871 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes binding
T930 1864-1876 SO_EXT:0000409 denotes binding site
T931 1896-1900 CHEMINF_GO_EXT:chemical_binding_or_bond_formation denotes bind
T932 1905-1910 PR_EXT:000015308 denotes Snail
T933 1911-1915 PR_EXT:000015309 denotes Slug
T934 1926-1930 CHEBI_EXT:zinc denotes zinc
T935 1938-1953 GO_EXT:transcription denotes transcriptional
T936 1964-1972 CHEBI_PR_EXT:protein denotes proteins

craft-sa-dev

Id Subject Object Predicate Lexical cue
T1495 4-7 DT denotes the
T1496 23-29 NNS denotes layers
T1497 8-11 CD denotes six
T1498 12-22 JJ denotes concentric
T1499 30-32 IN denotes of
T1500 33-36 DT denotes the
T1501 44-52 NN denotes follicle
T1502 37-43 JJ denotes mature
T1503 52-53 . denotes .
T1504 53-323 sentence denotes Previously, we delineated how two respective epithelial and mesenchymal signals, Wnts and the BMP-inhibitory factor noggin, function in concert to induce lymphoid enhancer factor-1/β-catenin (LEF-1/β-catenin)-mediated gene transcription within the follicle placode [4].
T1505 54-64 RB denotes Previously
T1506 69-79 VBD denotes delineated
T1507 64-66 , denotes ,
T1508 66-68 PRP denotes we
T1509 80-83 WRB denotes how
T1510 178-186 VBP denotes function
T1511 84-87 CD denotes two
T1512 126-133 NNS denotes signals
T1513 88-98 JJ denotes respective
T1514 99-109 JJ denotes epithelial
T1515 110-113 CC denotes and
T1516 114-125 JJ denotes mesenchymal
T1517 133-135 , denotes ,
T1518 135-139 NNS denotes Wnts
T1519 140-143 CC denotes and
T1520 144-147 DT denotes the
T1521 163-169 NN denotes factor
T1522 148-151 NN denotes BMP
T1523 152-162 JJ denotes inhibitory
T1524 151-152 HYPH denotes -
T1525 170-176 NN denotes noggin
T1526 176-178 , denotes ,
T1527 187-189 IN denotes in
T1528 190-197 NN denotes concert
T1529 198-200 TO denotes to
T1530 201-207 VB denotes induce
T1531 208-216 JJ denotes lymphoid
T1532 226-232 NN denotes factor
T1533 217-225 NN denotes enhancer
T1534 263-271 VBN denotes mediated
T1535 232-233 HYPH denotes -
T1536 233-234 CD denotes 1
T1537 234-235 HYPH denotes /
T1538 235-236 NN denotes β
T1539 237-244 NN denotes catenin
T1540 236-237 HYPH denotes -
T1541 245-246 -LRB- denotes (
T1542 246-249 NN denotes LEF
T1543 249-250 HYPH denotes -
T1544 250-251 CD denotes 1
T1545 251-252 HYPH denotes /
T1546 252-253 NN denotes β
T1547 254-261 NN denotes catenin
T1548 253-254 HYPH denotes -
T1549 261-262 -RRB- denotes )
T1550 262-263 HYPH denotes -
T1551 277-290 NN denotes transcription
T1552 272-276 NN denotes gene
T1553 291-297 IN denotes within
T1554 298-301 DT denotes the
T1555 311-318 NN denotes placode
T1556 302-310 NN denotes follicle
T1557 319-320 -LRB- denotes [
T1558 320-321 CD denotes 4
T1559 321-322 -RRB- denotes ]
T1560 322-323 . denotes .
T1561 323-588 sentence denotes The downstream changes elicited through convergence of these two early signaling pathways include down-regulation of the gene encoding E-cadherin, the prototypical epithelial cadherin that forms the transmembrane core of intercellular adherens junctions (AJs) [5].
T1562 324-327 DT denotes The
T1563 339-346 NNS denotes changes
T1564 328-338 JJ denotes downstream
T1565 414-421 VBP denotes include
T1566 347-355 VBN denotes elicited
T1567 356-363 IN denotes through
T1568 364-375 NN denotes convergence
T1569 376-378 IN denotes of
T1570 379-384 DT denotes these
T1571 405-413 NNS denotes pathways
T1572 385-388 CD denotes two
T1573 389-394 JJ denotes early
T1574 395-404 NN denotes signaling
T1575 422-426 JJ denotes down
T1576 427-437 NN denotes regulation
T1577 426-427 HYPH denotes -
T1578 438-440 IN denotes of
T1579 441-444 DT denotes the
T1580 445-449 NN denotes gene
T1581 450-458 VBG denotes encoding
T1582 459-460 NN denotes E
T1583 461-469 NN denotes cadherin
T1584 460-461 HYPH denotes -
T1585 469-471 , denotes ,
T1586 471-474 DT denotes the
T1587 499-507 NN denotes cadherin
T1588 475-487 JJ denotes prototypical
T1589 488-498 JJ denotes epithelial
T1590 508-512 WDT denotes that
T1591 513-518 VBZ denotes forms
T1592 519-522 DT denotes the
T1593 537-541 NN denotes core
T1594 523-536 JJ denotes transmembrane
T1595 542-544 IN denotes of
T1596 545-558 JJ denotes intercellular
T1597 568-577 NNS denotes junctions
T1598 559-567 NN denotes adherens
T1599 578-579 -LRB- denotes (
T1600 579-582 NNS denotes AJs
T1601 582-583 -RRB- denotes )
T1602 584-585 -LRB- denotes [
T1603 585-586 CD denotes 5
T1604 586-587 -RRB- denotes ]
T1605 587-588 . denotes .
T1606 588-853 sentence denotes We subsequently showed that when E-cadherin is transgenically elevated in mouse skin, hair follicle morphogenesis is blocked, suggesting that E-cadherin down-regulation is a critical event in governing the adhesion dynamics necessary for budding morphogenesis [4].
T1607 589-591 PRP denotes We
T1608 605-611 VBD denotes showed
T1609 592-604 RB denotes subsequently
T1610 612-616 IN denotes that
T1611 706-713 VBN denotes blocked
T1612 617-621 WRB denotes when
T1613 651-659 VBN denotes elevated
T1614 622-623 NN denotes E
T1615 624-632 NN denotes cadherin
T1616 623-624 HYPH denotes -
T1617 633-635 VBZ denotes is
T1618 636-650 RB denotes transgenically
T1619 660-662 IN denotes in
T1620 663-668 NN denotes mouse
T1621 669-673 NN denotes skin
T1622 673-675 , denotes ,
T1623 675-679 NN denotes hair
T1624 680-688 NN denotes follicle
T1625 689-702 NN denotes morphogenesis
T1626 703-705 VBZ denotes is
T1627 713-715 , denotes ,
T1628 715-725 VBG denotes suggesting
T1629 726-730 IN denotes that
T1630 758-760 VBZ denotes is
T1631 731-732 NN denotes E
T1632 733-741 NN denotes cadherin
T1633 732-733 HYPH denotes -
T1634 747-757 NN denotes regulation
T1635 742-746 JJ denotes down
T1636 746-747 HYPH denotes -
T1637 761-762 DT denotes a
T1638 772-777 NN denotes event
T1639 763-771 JJ denotes critical
T1640 778-780 IN denotes in
T1641 781-790 VBG denotes governing
T1642 791-794 DT denotes the
T1643 804-812 NNS denotes dynamics
T1644 795-803 NN denotes adhesion
T1645 813-822 JJ denotes necessary
T1646 823-826 IN denotes for
T1647 827-834 NN denotes budding
T1648 835-848 NN denotes morphogenesis
T1649 849-850 -LRB- denotes [
T1650 850-851 CD denotes 4
T1651 851-852 -RRB- denotes ]
T1652 852-853 . denotes .
T1653 853-901 sentence denotes Like LEF-1, E-cadherin also binds to β-catenin.
T1654 854-858 IN denotes Like
T1655 882-887 VBZ denotes binds
T1656 859-862 NN denotes LEF
T1657 862-863 HYPH denotes -
T1658 863-864 CD denotes 1
T1659 864-866 , denotes ,
T1660 866-867 NN denotes E
T1661 868-876 NN denotes cadherin
T1662 867-868 HYPH denotes -
T1663 877-881 RB denotes also
T1664 888-890 IN denotes to
T1665 891-892 NN denotes β
T1666 893-900 NN denotes catenin
T1667 892-893 HYPH denotes -
T1668 900-901 . denotes .
T1669 901-1164 sentence denotes At sites of cell-cell contact, however, E-cadherin-β-catenin complexes recruit α-catenin, which in turn coordinates the associated actin polymerization dynamics necessary to stabilize nascent AJs and integrate the cytoskeleton across an epithelial sheet [6,7,8].
T1670 902-904 IN denotes At
T1671 973-980 VBP denotes recruit
T1672 905-910 NNS denotes sites
T1673 911-913 IN denotes of
T1674 914-918 NN denotes cell
T1675 919-923 NN denotes cell
T1676 918-919 HYPH denotes -
T1677 924-931 NN denotes contact
T1678 931-933 , denotes ,
T1679 933-940 RB denotes however
T1680 940-942 , denotes ,
T1681 942-943 NN denotes E
T1682 944-952 NN denotes cadherin
T1683 943-944 HYPH denotes -
T1684 963-972 NNS denotes complexes
T1685 952-953 HYPH denotes -
T1686 953-954 NN denotes β
T1687 955-962 NN denotes catenin
T1688 954-955 HYPH denotes -
T1689 981-982 NN denotes α
T1690 983-990 NN denotes catenin
T1691 982-983 HYPH denotes -
T1692 990-992 , denotes ,
T1693 992-997 WDT denotes which
T1694 1006-1017 VBZ denotes coordinates
T1695 998-1000 IN denotes in
T1696 1001-1005 NN denotes turn
T1697 1018-1021 DT denotes the
T1698 1054-1062 NNS denotes dynamics
T1699 1022-1032 VBN denotes associated
T1700 1033-1038 NN denotes actin
T1701 1039-1053 NN denotes polymerization
T1702 1063-1072 JJ denotes necessary
T1703 1073-1075 TO denotes to
T1704 1076-1085 VB denotes stabilize
T1705 1086-1093 JJ denotes nascent
T1706 1094-1097 NNS denotes AJs
T1707 1098-1101 CC denotes and
T1708 1102-1111 VB denotes integrate
T1709 1112-1115 DT denotes the
T1710 1116-1128 NN denotes cytoskeleton
T1711 1129-1135 IN denotes across
T1712 1136-1138 DT denotes an
T1713 1150-1155 NN denotes sheet
T1714 1139-1149 JJ denotes epithelial
T1715 1156-1157 -LRB- denotes [
T1716 1161-1162 CD denotes 8
T1717 1157-1158 CD denotes 6
T1718 1158-1159 , denotes ,
T1719 1159-1160 CD denotes 7
T1720 1160-1161 , denotes ,
T1721 1162-1163 -RRB- denotes ]
T1722 1163-1164 . denotes .
T1723 1164-1421 sentence denotes α-Catenin also binds to the class III Lin-1, Isl-1, Mec-3 (LIM) protein Ajuba (a member of the zyxin family of proteins), which appears to function dually in both adhesion and in activation of the Ras-mitogen-activated protein kinase (MAPK) pathway [9,10].
T1724 1165-1166 NN denotes α
T1725 1167-1174 NN denotes Catenin
T1726 1166-1167 HYPH denotes -
T1727 1180-1185 VBZ denotes binds
T1728 1175-1179 RB denotes also
T1729 1186-1188 IN denotes to
T1730 1189-1192 DT denotes the
T1731 1229-1236 NN denotes protein
T1732 1193-1198 NN denotes class
T1733 1199-1202 CD denotes III
T1734 1203-1206 NN denotes Lin
T1735 1206-1207 HYPH denotes -
T1736 1207-1208 CD denotes 1
T1737 1208-1210 , denotes ,
T1738 1210-1213 NN denotes Isl
T1739 1213-1214 HYPH denotes -
T1740 1214-1215 CD denotes 1
T1741 1215-1217 , denotes ,
T1742 1217-1220 NN denotes Mec
T1743 1220-1221 HYPH denotes -
T1744 1221-1222 CD denotes 3
T1745 1223-1224 -LRB- denotes (
T1746 1224-1227 NN denotes LIM
T1747 1227-1228 -RRB- denotes )
T1748 1237-1242 NN denotes Ajuba
T1749 1243-1244 -LRB- denotes (
T1750 1244-1245 DT denotes a
T1751 1246-1252 NN denotes member
T1752 1253-1255 IN denotes of
T1753 1256-1259 DT denotes the
T1754 1266-1272 NN denotes family
T1755 1260-1265 NN denotes zyxin
T1756 1273-1275 IN denotes of
T1757 1276-1284 NN denotes proteins
T1758 1284-1285 -RRB- denotes )
T1759 1285-1287 , denotes ,
T1760 1287-1292 WDT denotes which
T1761 1293-1300 VBZ denotes appears
T1762 1301-1303 TO denotes to
T1763 1304-1312 VB denotes function
T1764 1313-1319 RB denotes dually
T1765 1320-1322 IN denotes in
T1766 1323-1327 CC denotes both
T1767 1328-1336 NN denotes adhesion
T1768 1337-1340 CC denotes and
T1769 1341-1343 IN denotes in
T1770 1344-1354 NN denotes activation
T1771 1355-1357 IN denotes of
T1772 1358-1361 DT denotes the
T1773 1406-1413 NN denotes pathway
T1774 1362-1365 NN denotes Ras
T1775 1365-1366 HYPH denotes -
T1776 1366-1373 NN denotes mitogen
T1777 1374-1383 VBN denotes activated
T1778 1373-1374 HYPH denotes -
T1779 1392-1398 NN denotes kinase
T1780 1384-1391 NN denotes protein
T1781 1399-1400 -LRB- denotes (
T1782 1400-1404 NN denotes MAPK
T1783 1404-1405 -RRB- denotes )
T1784 1414-1415 -LRB- denotes [
T1785 1417-1419 CD denotes 10
T1786 1415-1416 CD denotes 9
T1787 1416-1417 , denotes ,
T1788 1419-1420 -RRB- denotes ]
T1789 1420-1421 . denotes .
T1790 1421-1555 sentence denotes Through these links, AJs appear able to couple adhesion with cytoskeletal dynamics as well as with nuclear and cytoplasmic signaling.
T1791 1422-1429 IN denotes Through
T1792 1447-1453 VBP denotes appear
T1793 1430-1435 DT denotes these
T1794 1436-1441 NNS denotes links
T1795 1441-1443 , denotes ,
T1796 1443-1446 NNS denotes AJs
T1797 1454-1458 JJ denotes able
T1798 1459-1461 TO denotes to
T1799 1462-1468 VB denotes couple
T1800 1469-1477 NN denotes adhesion
T1801 1478-1482 IN denotes with
T1802 1483-1495 JJ denotes cytoskeletal
T1803 1496-1504 NNS denotes dynamics
T1804 1505-1507 RB denotes as
T1805 1513-1515 IN denotes as
T1806 1508-1512 RB denotes well
T1807 1516-1520 IN denotes with
T1808 1521-1528 JJ denotes nuclear
T1809 1545-1554 NN denotes signaling
T1810 1529-1532 CC denotes and
T1811 1533-1544 JJ denotes cytoplasmic
T1812 1554-1555 . denotes .
T1813 1555-1703 sentence denotes This provides a framework for conceptualizing why E-cadherin levels appear to impact upon a plethora of developmental processes (reviewed in [11]).
T1814 1556-1560 DT denotes This
T1815 1561-1569 VBZ denotes provides
T1816 1570-1571 DT denotes a
T1817 1572-1581 NN denotes framework
T1818 1582-1585 IN denotes for
T1819 1586-1601 VBG denotes conceptualizing
T1820 1602-1605 WRB denotes why
T1821 1624-1630 VBP denotes appear
T1822 1606-1607 NN denotes E
T1823 1608-1616 NN denotes cadherin
T1824 1607-1608 HYPH denotes -
T1825 1617-1623 NNS denotes levels
T1826 1631-1633 TO denotes to
T1827 1634-1640 VB denotes impact
T1828 1641-1645 IN denotes upon
T1829 1646-1647 DT denotes a
T1830 1648-1656 NN denotes plethora
T1831 1657-1659 IN denotes of
T1832 1660-1673 JJ denotes developmental
T1833 1674-1683 NNS denotes processes
T1834 1684-1685 -LRB- denotes (
T1835 1685-1693 VBN denotes reviewed
T1836 1694-1696 IN denotes in
T1837 1697-1698 -LRB- denotes [
T1838 1698-1700 CD denotes 11
T1839 1700-1701 -RRB- denotes ]
T1840 1701-1702 -RRB- denotes )
T1841 1702-1703 . denotes .
T1843 1704-1706 IN denotes As
T1844 1710-1716 VBD denotes probed
T1845 1707-1709 PRP denotes we
T1846 1808-1817 VBN denotes intrigued
T1847 1717-1721 RBR denotes more
T1848 1722-1728 RB denotes deeply
T1849 1729-1733 IN denotes into
T1850 1734-1737 DT denotes the
T1851 1749-1759 NNS denotes mechanisms
T1852 1738-1748 JJ denotes underlying
T1853 1760-1769 VBG denotes governing
T1854 1770-1771 NN denotes E
T1855 1772-1780 NN denotes cadherin
T1856 1771-1772 HYPH denotes -
T1857 1781-1789 NN denotes promoter
T1858 1790-1798 NN denotes activity
T1859 1798-1800 , denotes ,
T1860 1800-1802 PRP denotes we
T1861 1803-1807 VBD denotes were
T1862 1818-1820 IN denotes by
T1863 1821-1824 DT denotes the
T1864 1831-1840 NN denotes proximity
T1865 1825-1830 JJ denotes close
T1866 1841-1843 IN denotes of
T1867 1844-1847 DT denotes the
T1868 1872-1876 NN denotes site
T1869 1848-1851 NN denotes LEF
T1870 1851-1852 HYPH denotes -
T1871 1852-1853 CD denotes 1
T1872 1853-1854 HYPH denotes /
T1873 1854-1855 NN denotes β
T1874 1856-1863 NN denotes catenin
T1875 1855-1856 HYPH denotes -
T1876 1864-1871 NN denotes binding
T1877 1877-1879 IN denotes to
T1878 1880-1881 DT denotes a
T1879 1882-1886 NN denotes site
T1880 1887-1892 VBN denotes known
T1881 1893-1895 TO denotes to
T1882 1896-1900 VB denotes bind
T1883 1901-1904 DT denotes the
T1884 1916-1922 NN denotes family
T1885 1905-1910 NN denotes Snail
T1886 1911-1915 NN denotes Slug
T1887 1910-1911 HYPH denotes /
T1888 1923-1925 IN denotes of
T1889 1926-1930 NN denotes zinc
T1890 1931-1937 NN denotes finger
T1891 1964-1972 NN denotes proteins
T1892 1938-1953 JJ denotes transcriptional
T1893 1954-1963 NN denotes repressor
T1894 1973-1974 -LRB- denotes [
T1896 1974-1976 CD denotes 12
T1897 1976-1977 , denotes ,
T1898 1977-1979 CD denotes 13
T1899 1979-1980 , denotes ,
T1900 1980-1982 CD denotes 14
R672 T1495 T1496 det the,layers
R674 T1497 T1496 nummod six,layers
R675 T1498 T1496 amod concentric,layers
R676 T1499 T1496 prep of,layers
R677 T1500 T1501 det the,follicle
R678 T1501 T1499 pobj follicle,of
R679 T1502 T1501 amod mature,follicle
R681 T1505 T1506 advmod Previously,delineated
R682 T1507 T1506 punct ", ",delineated
R683 T1508 T1506 nsubj we,delineated
R684 T1509 T1510 advmod how,function
R685 T1510 T1506 ccomp function,delineated
R686 T1511 T1512 nummod two,signals
R687 T1512 T1510 nsubj signals,function
R688 T1513 T1512 amod respective,signals
R689 T1514 T1512 amod epithelial,signals
R690 T1515 T1514 cc and,epithelial
R691 T1516 T1514 conj mesenchymal,epithelial
R692 T1517 T1512 punct ", ",signals
R693 T1518 T1512 appos Wnts,signals
R694 T1519 T1518 cc and,Wnts
R695 T1520 T1521 det the,factor
R696 T1521 T1518 conj factor,Wnts
R697 T1522 T1523 npadvmod BMP,inhibitory
R698 T1523 T1521 amod inhibitory,factor
R699 T1524 T1523 punct -,inhibitory
R700 T1525 T1521 appos noggin,factor
R701 T1526 T1510 punct ", ",function
R702 T1527 T1510 prep in,function
R703 T1528 T1527 pobj concert,in
R704 T1529 T1530 aux to,induce
R705 T1530 T1510 advcl induce,function
R706 T1531 T1532 amod lymphoid,factor
R707 T1532 T1534 npadvmod factor,mediated
R708 T1533 T1532 compound enhancer,factor
R709 T1534 T1551 amod mediated,transcription
R710 T1535 T1532 punct -,factor
R711 T1536 T1532 nummod 1,factor
R712 T1537 T1532 punct /,factor
R713 T1538 T1539 compound β,catenin
R714 T1539 T1532 appos catenin,factor
R715 T1540 T1539 punct -,catenin
R716 T1541 T1532 punct (,factor
R717 T1542 T1532 appos LEF,factor
R718 T1543 T1542 punct -,LEF
R719 T1544 T1542 nummod 1,LEF
R720 T1545 T1542 punct /,LEF
R721 T1546 T1547 compound β,catenin
R722 T1547 T1542 appos catenin,LEF
R723 T1548 T1547 punct -,catenin
R724 T1549 T1534 punct ),mediated
R725 T1550 T1534 punct -,mediated
R726 T1551 T1530 dobj transcription,induce
R727 T1552 T1551 compound gene,transcription
R728 T1553 T1530 prep within,induce
R729 T1554 T1555 det the,placode
R730 T1555 T1553 pobj placode,within
R731 T1556 T1555 compound follicle,placode
R732 T1557 T1558 punct [,4
R733 T1558 T1506 parataxis 4,delineated
R734 T1559 T1558 punct ],4
R735 T1560 T1506 punct .,delineated
R736 T1562 T1563 det The,changes
R737 T1563 T1565 nsubj changes,include
R738 T1564 T1563 amod downstream,changes
R739 T1566 T1563 acl elicited,changes
R740 T1567 T1566 prep through,elicited
R741 T1568 T1567 pobj convergence,through
R742 T1569 T1568 prep of,convergence
R743 T1675 T1677 compound cell,contact
R744 T1676 T1675 punct -,cell
R745 T1677 T1673 pobj contact,of
R746 T1678 T1671 punct ", ",recruit
R747 T1679 T1671 advmod however,recruit
R748 T1570 T1571 det these,pathways
R749 T1680 T1671 punct ", ",recruit
R750 T1571 T1569 pobj pathways,of
R751 T1681 T1682 nmod E,cadherin
R752 T1572 T1571 nummod two,pathways
R753 T1573 T1571 amod early,pathways
R754 T1682 T1684 nmod cadherin,complexes
R755 T1574 T1571 compound signaling,pathways
R756 T1575 T1576 amod down,regulation
R757 T1683 T1682 punct -,cadherin
R758 T1576 T1565 dobj regulation,include
R759 T1577 T1576 punct -,regulation
R760 T1578 T1576 prep of,regulation
R761 T1684 T1671 nsubj complexes,recruit
R762 T1579 T1580 det the,gene
R763 T1580 T1578 pobj gene,of
R764 T1685 T1682 punct -,cadherin
R765 T1581 T1580 acl encoding,gene
R766 T1582 T1583 compound E,cadherin
R767 T1583 T1581 dobj cadherin,encoding
R768 T1686 T1687 compound β,catenin
R769 T1584 T1583 punct -,cadherin
R770 T1585 T1583 punct ", ",cadherin
R771 T1586 T1587 det the,cadherin
R772 T1687 T1682 appos catenin,cadherin
R773 T1587 T1583 appos cadherin,cadherin
R774 T1588 T1587 amod prototypical,cadherin
R775 T1688 T1687 punct -,catenin
R776 T1589 T1587 amod epithelial,cadherin
R777 T1590 T1591 dep that,forms
R778 T1591 T1587 relcl forms,cadherin
R779 T1689 T1690 compound α,catenin
R780 T1592 T1593 det the,core
R781 T1593 T1591 dobj core,forms
R782 T1690 T1671 dobj catenin,recruit
R783 T1594 T1593 amod transmembrane,core
R784 T1595 T1593 prep of,core
R785 T1596 T1597 amod intercellular,junctions
R786 T1691 T1690 punct -,catenin
R787 T1597 T1595 pobj junctions,of
R788 T1598 T1597 compound adherens,junctions
R789 T1599 T1597 punct (,junctions
R790 T1692 T1690 punct ", ",catenin
R791 T1600 T1597 appos AJs,junctions
R792 T1601 T1565 punct ),include
R793 T1602 T1603 punct [,5
R794 T1603 T1565 parataxis 5,include
R795 T1604 T1603 punct ],5
R796 T1693 T1694 dep which,coordinates
R797 T1605 T1565 punct .,include
R798 T1607 T1608 nsubj We,showed
R799 T1694 T1690 relcl coordinates,catenin
R800 T1609 T1608 advmod subsequently,showed
R801 T1695 T1694 prep in,coordinates
R802 T1610 T1611 mark that,blocked
R803 T1696 T1695 pobj turn,in
R804 T1611 T1608 ccomp blocked,showed
R805 T1697 T1698 det the,dynamics
R806 T1612 T1613 advmod when,elevated
R807 T1613 T1611 advcl elevated,blocked
R808 T1698 T1694 dobj dynamics,coordinates
R809 T1614 T1615 compound E,cadherin
R810 T1615 T1613 nsubjpass cadherin,elevated
R811 T1616 T1615 punct -,cadherin
R812 T1699 T1698 amod associated,dynamics
R813 T1617 T1613 auxpass is,elevated
R814 T1618 T1613 advmod transgenically,elevated
R815 T1700 T1698 compound actin,dynamics
R816 T1619 T1613 prep in,elevated
R817 T1620 T1621 compound mouse,skin
R818 T1621 T1619 pobj skin,in
R819 T1701 T1698 compound polymerization,dynamics
R820 T1622 T1611 punct ", ",blocked
R821 T1623 T1624 compound hair,follicle
R822 T1624 T1625 compound follicle,morphogenesis
R823 T1702 T1698 amod necessary,dynamics
R824 T1625 T1611 nsubjpass morphogenesis,blocked
R825 T1626 T1611 auxpass is,blocked
R826 T1627 T1611 punct ", ",blocked
R827 T1703 T1704 aux to,stabilize
R828 T1628 T1611 advcl suggesting,blocked
R829 T1629 T1630 mark that,is
R830 T1630 T1628 ccomp is,suggesting
R831 T1704 T1702 xcomp stabilize,necessary
R832 T1631 T1632 nmod E,cadherin
R833 T1632 T1634 nmod cadherin,regulation
R834 T1705 T1706 amod nascent,AJs
R835 T1633 T1632 punct -,cadherin
R836 T1634 T1630 nsubj regulation,is
R837 T1635 T1634 amod down,regulation
R838 T1706 T1704 dobj AJs,stabilize
R839 T1636 T1634 punct -,regulation
R840 T1637 T1638 det a,event
R841 T1638 T1630 attr event,is
R842 T1639 T1638 amod critical,event
R843 T1640 T1638 prep in,event
R844 T1707 T1704 cc and,stabilize
R845 T1708 T1704 conj integrate,stabilize
R846 T1641 T1640 pcomp governing,in
R847 T1709 T1710 det the,cytoskeleton
R848 T1642 T1643 det the,dynamics
R849 T1643 T1641 dobj dynamics,governing
R850 T1644 T1643 compound adhesion,dynamics
R851 T1710 T1708 dobj cytoskeleton,integrate
R852 T1645 T1643 amod necessary,dynamics
R853 T1646 T1645 prep for,necessary
R854 T1647 T1648 compound budding,morphogenesis
R855 T1711 T1708 prep across,integrate
R856 T1648 T1646 pobj morphogenesis,for
R857 T1649 T1650 punct [,4
R858 T1712 T1713 det an,sheet
R859 T1650 T1608 parataxis 4,showed
R860 T1651 T1650 punct ],4
R861 T1652 T1608 punct .,showed
R862 T1713 T1711 pobj sheet,across
R863 T1654 T1655 prep Like,binds
R864 T1714 T1713 amod epithelial,sheet
R865 T1656 T1654 pobj LEF,Like
R866 T1657 T1656 punct -,LEF
R867 T1715 T1716 punct [,8
R868 T1658 T1656 nummod 1,LEF
R869 T1659 T1655 punct ", ",binds
R870 T1660 T1661 compound E,cadherin
R871 T1661 T1655 nsubj cadherin,binds
R872 T1716 T1694 parataxis 8,coordinates
R873 T1662 T1661 punct -,cadherin
R874 T1663 T1655 advmod also,binds
R875 T1717 T1716 nummod 6,8
R876 T1664 T1655 prep to,binds
R877 T1665 T1666 compound β,catenin
R878 T1666 T1664 pobj catenin,to
R879 T1718 T1716 punct ",",8
R880 T1667 T1666 punct -,catenin
R881 T1668 T1655 punct .,binds
R882 T1719 T1716 nummod 7,8
R883 T1670 T1671 prep At,recruit
R884 T1720 T1716 punct ",",8
R885 T1672 T1670 pobj sites,At
R886 T1673 T1672 prep of,sites
R887 T1674 T1675 compound cell,cell
R888 T1721 T1716 punct ],8
R889 T1722 T1671 punct .,recruit
R890 T1724 T1725 compound α,Catenin
R891 T1725 T1727 nsubj Catenin,binds
R892 T1726 T1725 punct -,Catenin
R893 T1780 T1779 compound protein,kinase
R894 T1781 T1779 punct (,kinase
R895 T1782 T1779 appos MAPK,kinase
R896 T1728 T1727 advmod also,binds
R897 T1783 T1773 punct ),pathway
R898 T1784 T1785 punct [,10
R899 T1729 T1727 prep to,binds
R900 T1785 T1727 parataxis 10,binds
R901 T1786 T1785 nummod 9,10
R902 T1730 T1731 det the,protein
R903 T1787 T1785 punct ",",10
R904 T1788 T1785 punct ],10
R905 T1731 T1729 pobj protein,to
R906 T1789 T1727 punct .,binds
R907 T1732 T1731 nmod class,protein
R908 T1791 T1792 prep Through,appear
R909 T1793 T1794 det these,links
R910 T1733 T1732 nummod III,class
R911 T1794 T1791 pobj links,Through
R912 T1795 T1792 punct ", ",appear
R913 T1734 T1731 nmod Lin,protein
R914 T1796 T1792 nsubj AJs,appear
R915 T1797 T1792 oprd able,appear
R916 T1798 T1799 aux to,couple
R917 T1735 T1734 punct -,Lin
R918 T1799 T1797 xcomp couple,able
R919 T1800 T1799 dobj adhesion,couple
R920 T1736 T1734 nummod 1,Lin
R921 T1801 T1799 prep with,couple
R922 T1802 T1803 amod cytoskeletal,dynamics
R923 T1803 T1801 pobj dynamics,with
R924 T1737 T1734 punct ", ",Lin
R925 T1804 T1805 advmod as,as
R926 T1805 T1801 cc as,with
R927 T1806 T1805 advmod well,as
R928 T1738 T1734 appos Isl,Lin
R929 T1807 T1801 conj with,with
R930 T1808 T1809 amod nuclear,signaling
R931 T1739 T1738 punct -,Isl
R932 T1809 T1807 pobj signaling,with
R933 T1810 T1808 cc and,nuclear
R934 T1811 T1808 conj cytoplasmic,nuclear
R935 T1740 T1738 nummod 1,Isl
R936 T1812 T1792 punct .,appear
R937 T1814 T1815 nsubj This,provides
R938 T1741 T1734 punct ", ",Lin
R939 T1816 T1817 det a,framework
R940 T1742 T1734 appos Mec,Lin
R941 T1817 T1815 dobj framework,provides
R942 T1818 T1817 prep for,framework
R943 T1819 T1818 pcomp conceptualizing,for
R944 T1820 T1821 advmod why,appear
R945 T1821 T1819 ccomp appear,conceptualizing
R946 T1822 T1823 compound E,cadherin
R947 T1743 T1742 punct -,Mec
R948 T1823 T1825 compound cadherin,levels
R949 T1824 T1823 punct -,cadherin
R950 T1825 T1821 nsubj levels,appear
R951 T1826 T1827 aux to,impact
R952 T1744 T1742 nummod 3,Mec
R953 T1827 T1821 xcomp impact,appear
R954 T1828 T1827 prep upon,impact
R955 T1745 T1734 punct (,Lin
R956 T1829 T1830 det a,plethora
R957 T1830 T1828 pobj plethora,upon
R958 T1831 T1830 prep of,plethora
R959 T1746 T1734 appos LIM,Lin
R960 T1832 T1833 amod developmental,processes
R961 T1833 T1831 pobj processes,of
R962 T1834 T1835 punct (,reviewed
R963 T1747 T1731 punct ),protein
R964 T1835 T1815 parataxis reviewed,provides
R965 T1836 T1835 prep in,reviewed
R966 T1837 T1836 punct [,in
R967 T1748 T1731 appos Ajuba,protein
R968 T1838 T1836 pobj 11,in
R969 T1839 T1835 punct ],reviewed
R970 T1840 T1835 punct ),reviewed
R971 T1749 T1731 punct (,protein
R972 T1841 T1815 punct .,provides
R973 T1750 T1751 det a,member
R974 T1843 T1844 mark As,probed
R975 T1844 T1846 advcl probed,intrigued
R976 T1845 T1844 nsubj we,probed
R977 T1751 T1731 appos member,protein
R978 T1847 T1848 advmod more,deeply
R979 T1848 T1844 advmod deeply,probed
R980 T1752 T1751 prep of,member
R981 T1849 T1844 prep into,probed
R982 T1850 T1851 det the,mechanisms
R983 T1851 T1849 pobj mechanisms,into
R984 T1753 T1754 det the,family
R985 T1852 T1851 amod underlying,mechanisms
R986 T1853 T1851 acl governing,mechanisms
R987 T1854 T1855 compound E,cadherin
R988 T1754 T1752 pobj family,of
R989 T1855 T1857 compound cadherin,promoter
R990 T1856 T1855 punct -,cadherin
R991 T1857 T1858 compound promoter,activity
R992 T1755 T1754 compound zyxin,family
R993 T1858 T1853 dobj activity,governing
R994 T1859 T1846 punct ", ",intrigued
R995 T1756 T1754 prep of,family
R996 T1860 T1846 nsubjpass we,intrigued
R997 T1861 T1846 auxpass were,intrigued
R998 T1862 T1846 agent by,intrigued
R999 T1863 T1864 det the,proximity
R1000 T1864 T1862 pobj proximity,by
R1001 T1865 T1864 amod close,proximity
R1002 T1757 T1756 pobj proteins,of
R1003 T1866 T1864 prep of,proximity
R1004 T1867 T1868 det the,site
R1005 T1758 T1731 punct ),protein
R1006 T1759 T1731 punct ", ",protein
R1007 T1868 T1866 pobj site,of
R1008 T1869 T1868 nmod LEF,site
R1009 T1870 T1869 punct -,LEF
R1010 T1760 T1761 dep which,appears
R1011 T1871 T1869 nummod 1,LEF
R1012 T1872 T1869 punct /,LEF
R1013 T1761 T1731 relcl appears,protein
R1014 T1873 T1874 compound β,catenin
R1015 T1762 T1763 aux to,function
R1016 T1874 T1869 appos catenin,LEF
R1017 T1875 T1874 punct -,catenin
R1018 T1876 T1868 compound binding,site
R1019 T1763 T1761 xcomp function,appears
R1020 T1877 T1864 prep to,proximity
R1021 T1878 T1879 det a,site
R1022 T1879 T1877 pobj site,to
R1023 T1764 T1763 advmod dually,function
R1024 T1880 T1879 acl known,site
R1025 T1881 T1882 aux to,bind
R1026 T1765 T1763 prep in,function
R1027 T1882 T1880 xcomp bind,known
R1028 T1883 T1884 det the,family
R1029 T1884 T1882 dobj family,bind
R1030 T1766 T1765 preconj both,in
R1031 T1767 T1765 conj adhesion,in
R1032 T1768 T1765 cc and,in
R1033 T1769 T1765 conj in,in
R1034 T1885 T1886 compound Snail,Slug
R1035 T1886 T1884 compound Slug,family
R1036 T1770 T1769 pobj activation,in
R1037 T1887 T1886 punct /,Slug
R1038 T1888 T1884 prep of,family
R1039 T1889 T1890 nmod zinc,finger
R1040 T1771 T1770 prep of,activation
R1041 T1890 T1891 nmod finger,proteins
R1042 T1891 T1888 pobj proteins,of
R1043 T1772 T1773 det the,pathway
R1044 T1892 T1893 amod transcriptional,repressor
R1045 T1893 T1891 compound repressor,proteins
R1047 T1773 T1771 pobj pathway,of
R1054 T1774 T1773 nmod Ras,pathway
R1058 T1775 T1774 punct -,Ras
R1060 T1776 T1777 npadvmod mitogen,activated
R1063 T1777 T1779 amod activated,kinase
R1067 T1778 T1777 punct -,activated
R1071 T1779 T1774 appos kinase,Ras