Criteria Yes Proportion of studies fulfilled criteria 1. Is the study population clearly described? [3–25–26–27–28–29–30–31–33–34–36–37–38–39–42–43–44–45–46–47–48–49–50–51–53–54] 87% 2. Are competing alternatives clearly described? [3–25–26–27–28–29–30–31–32–33–36–37–38–39–40–41–42–43–44–45–46–47– 48–49–50–51–53–54] 97% 3. Is a well-defined research question posed in answerable form? [3–25–26–27–28–29–30–31–32–33–36–37–38–39–40–41–42–43–44–45–46–47– 48–49–50–51–53–54] 97% 4. Is the economic study design appropriate to the stated objective? [3–25–26–32–33–37–38–39–40–41–42–44–45–46–47–49–50–51] 63% 5. Is the chosen time horizon appropriate in order to include relevant costs and consequences? [3–25–26–27–28–29–30–31–32–33–34–36–37–38–39–40–41–44–45–47–48–49–50–51–53–54] 90% 6. Is the actual perspective chosen appropriate? [3–25–26–28–29–30–31–32–33–36–37–38–39–40–41–42–43–47–49–50–51–53–54] 80% 7. Are all important and relevant costs for each alternative identified? [3–25–26–27–28–29–30–31–33–34–36–37–38–39–41–42–43–45–48–49–51–53–54] 60% 8. Are all costs measured appropriately in physical units? [3–25–26–28–30–31–32–33–36–37–38–39–40–41–42–43–45––47– 48–49–50–51–53–54] 80% 9. Are costs valued appropriately? [3–26–29–30–31–32–33–36–37–39–46–47–50–53–54] 83% 10. Are all important and relevant outcomes for each alternative identified? [3–29–30–31–32–33–36–37–39–46–47–50–53–54] 53% 11. Are all outcomes measured appropriately? [3–26–27–28–30–31–33–34–36–37–39–40–41–42–45–46–50–53–54] 67% 12. Are outcomes valued appropriately? [3–26–28–29–30–31–32–33–36–37–39–40–41–42–45–46–47–50–53–54] 70% 13. Is an incremental analysis of costs and outcomes of alternatives performed? [3–26–29–32–37–39–40–41–42–45–47–50–54] 43% 14. Are all future costs and outcomes discounted appropriately? [3–26–27–28–29–31–32–33–36–38–39–40–41–42–43–45–47–48–49–50–53–54] 76% 15. Are all important variables, whose values are uncertain, appropriately subjected to sensitivity analysis? [27–28–33–36–37–38–39–40–41–42–47–49–50–54] 50% 16. Do the conclusions follow from the data reported? [3–25–26–27–28–29–30–31–32–33–34–36–37–38–39–40–41–42–43–44–45–46–47–48–49–50–51–53–54] 100% 17. Does the study discuss the generalizability of the results to other settings and patient/client groups? [3–25–27–28–29–30–31–32–33–34–36–37–38–40–41–42–44–45–46–47–50–53–54] 80% 18. Does the article indicate that there is no potential conflict of interest of study researcher(s) and funder(s)? [3–26–27–30–31–32–34–37–38–39–40–41–42–44–45–46–47–49–50–51–53–54] 73% 19. Are ethical and distributional issues discussed appropriately? [3–27–30–31–33–35–36–37–44–46–53–54] 43%