Sensory Axons Labeled with DiI through the DRG at E17
(A) DiI-labeled fibers in WT spinal cord. Notice proprioceptive axons extending towards the motor neurons located in the ventral horn of the spinal cord in cross section.
(B) Bax null spinal cord.
(C) NT-3 null spinal cord. Stained fibers are restricted to the nociceptive axons in the dorsal horn, as evidenced by the complete absence of labeling in the ventral spinal cord.
(D) Bax/NT-3 double null spinal cord. Although fibers extend into the ventral spinal cord, they never grow towards the motor neurons, but are directed towards the midline instead.
Scale bar: 100 μm.