Recently, Patel et al. (2003) reported their observations on Bax/NT-3 double KO mice they bred. Their results are significantly different from ours. They see no proprioceptive afferents in the periphery of the double knockouts and note that central proprioceptive afferents terminate in the intermediate spinal cord without extending ventrally. Their observations are based on PV immunostaining and DiI labeling of the peripheral nerves. We noted that PV immunolabeling is diminished in our Bax/NT-3 double KOs. In various manipulations of the neurotrophins it has been noted that molecular markers for proprioceptive axons such as PV or calcitonin gene-related peptide for nerve growth factor–responsive axons are compromised (Ringstedt et al. 1997; Patel et al. 2000), thus PV immunostaining in Bax/NT-3 double KOs cannot reveal the extent of proprioceptive axons in the periphery.