Id |
Subject |
Object |
Predicate |
Lexical cue |
T237 |
0-3 |
NN |
denotes |
BMP |
T238 |
4-12 |
NN |
denotes |
Receptor |
T239 |
0-83 |
sentence |
denotes |
BMP Receptor Signaling Is Required for Postnatal Maintenance of Articular Cartilage |
T240 |
13-22 |
NN |
denotes |
Signaling |
T241 |
26-34 |
VBN |
denotes |
Required |
T242 |
23-25 |
VBZ |
denotes |
Is |
T243 |
35-38 |
IN |
denotes |
for |
T244 |
39-48 |
JJ |
denotes |
Postnatal |
T245 |
49-60 |
NN |
denotes |
Maintenance |
T246 |
61-63 |
IN |
denotes |
of |
T247 |
64-73 |
JJ |
denotes |
Articular |
T248 |
74-83 |
NN |
denotes |
Cartilage |
T250 |
128-275 |
sentence |
denotes |
Articular cartilage plays an essential role in health and mobility, but is frequently damaged or lost in millions of people that develop arthritis. |
T251 |
128-137 |
JJ |
denotes |
Articular |
T252 |
138-147 |
NN |
denotes |
cartilage |
T253 |
148-153 |
VBZ |
denotes |
plays |
T254 |
154-156 |
DT |
denotes |
an |
T255 |
167-171 |
NN |
denotes |
role |
T256 |
157-166 |
JJ |
denotes |
essential |
T257 |
172-174 |
IN |
denotes |
in |
T258 |
175-181 |
NN |
denotes |
health |
T259 |
182-185 |
CC |
denotes |
and |
T260 |
186-194 |
NN |
denotes |
mobility |
T261 |
194-196 |
, |
denotes |
, |
T262 |
196-199 |
CC |
denotes |
but |
T263 |
200-202 |
VBZ |
denotes |
is |
T264 |
214-221 |
VBN |
denotes |
damaged |
T265 |
203-213 |
RB |
denotes |
frequently |
T266 |
222-224 |
CC |
denotes |
or |
T267 |
225-229 |
VBN |
denotes |
lost |
T268 |
230-232 |
IN |
denotes |
in |
T269 |
233-241 |
NNS |
denotes |
millions |
T270 |
242-244 |
IN |
denotes |
of |
T271 |
245-251 |
NNS |
denotes |
people |
T272 |
252-256 |
WDT |
denotes |
that |
T273 |
257-264 |
VBP |
denotes |
develop |
T274 |
265-274 |
NN |
denotes |
arthritis |
T275 |
274-275 |
. |
denotes |
. |
T276 |
275-532 |
sentence |
denotes |
The molecular mechanisms that create and maintain this thin layer of cartilage that covers the surface of bones in joint regions are poorly understood, in part because tools to manipulate gene expression specifically in this tissue have not been available. |
T277 |
276-279 |
DT |
denotes |
The |
T278 |
290-300 |
NNS |
denotes |
mechanisms |
T279 |
280-289 |
JJ |
denotes |
molecular |
T280 |
416-426 |
VBN |
denotes |
understood |
T281 |
301-305 |
WDT |
denotes |
that |
T282 |
306-312 |
VBP |
denotes |
create |
T283 |
313-316 |
CC |
denotes |
and |
T284 |
317-325 |
VBP |
denotes |
maintain |
T285 |
326-330 |
DT |
denotes |
this |
T286 |
336-341 |
NN |
denotes |
layer |
T287 |
331-335 |
JJ |
denotes |
thin |
T288 |
342-344 |
IN |
denotes |
of |
T289 |
345-354 |
NN |
denotes |
cartilage |
T290 |
355-359 |
WDT |
denotes |
that |
T291 |
360-366 |
VBZ |
denotes |
covers |
T292 |
367-370 |
DT |
denotes |
the |
T293 |
371-378 |
NN |
denotes |
surface |
T294 |
379-381 |
IN |
denotes |
of |
T295 |
382-387 |
NNS |
denotes |
bones |
T296 |
388-390 |
IN |
denotes |
in |
T297 |
391-396 |
NN |
denotes |
joint |
T298 |
397-404 |
NNS |
denotes |
regions |
T299 |
405-408 |
VBP |
denotes |
are |
T300 |
409-415 |
RB |
denotes |
poorly |
T301 |
426-428 |
, |
denotes |
, |
T302 |
428-430 |
IN |
denotes |
in |
T303 |
517-521 |
VBN |
denotes |
been |
T304 |
431-435 |
JJ |
denotes |
part |
T305 |
436-443 |
IN |
denotes |
because |
T306 |
444-449 |
NNS |
denotes |
tools |
T307 |
450-452 |
TO |
denotes |
to |
T308 |
453-463 |
VB |
denotes |
manipulate |
T309 |
464-468 |
NN |
denotes |
gene |
T310 |
469-479 |
NN |
denotes |
expression |
T311 |
480-492 |
RB |
denotes |
specifically |
T312 |
493-495 |
IN |
denotes |
in |
T313 |
496-500 |
DT |
denotes |
this |
T314 |
501-507 |
NN |
denotes |
tissue |
T315 |
508-512 |
VBP |
denotes |
have |
T316 |
513-516 |
RB |
denotes |
not |
T317 |
522-531 |
JJ |
denotes |
available |
T318 |
531-532 |
. |
denotes |
. |
T319 |
532-761 |
sentence |
denotes |
Here we use regulatory information from the mouse Gdf5 gene (a bone morphogenetic protein [BMP] family member) to develop new mouse lines that can be used to either activate or inactivate genes specifically in developing joints. |
T320 |
533-537 |
RB |
denotes |
Here |
T321 |
541-544 |
VBP |
denotes |
use |
T322 |
538-540 |
PRP |
denotes |
we |
T323 |
545-555 |
JJ |
denotes |
regulatory |
T324 |
556-567 |
NN |
denotes |
information |
T325 |
568-572 |
IN |
denotes |
from |
T326 |
573-576 |
DT |
denotes |
the |
T327 |
588-592 |
NN |
denotes |
gene |
T328 |
577-582 |
NN |
denotes |
mouse |
T329 |
583-587 |
NN |
denotes |
Gdf5 |
T330 |
593-594 |
-LRB- |
denotes |
( |
T331 |
636-642 |
NN |
denotes |
member |
T332 |
594-595 |
DT |
denotes |
a |
T333 |
596-600 |
NN |
denotes |
bone |
T334 |
615-622 |
NN |
denotes |
protein |
T335 |
601-614 |
JJ |
denotes |
morphogenetic |
T336 |
623-624 |
-LRB- |
denotes |
[ |
T337 |
624-627 |
NN |
denotes |
BMP |
T338 |
627-628 |
-RRB- |
denotes |
] |
T339 |
629-635 |
NN |
denotes |
family |
T340 |
642-643 |
-RRB- |
denotes |
) |
T341 |
644-646 |
TO |
denotes |
to |
T342 |
647-654 |
VB |
denotes |
develop |
T343 |
655-658 |
JJ |
denotes |
new |
T344 |
665-670 |
NNS |
denotes |
lines |
T345 |
659-664 |
NN |
denotes |
mouse |
T346 |
671-675 |
WDT |
denotes |
that |
T347 |
683-687 |
VBN |
denotes |
used |
T348 |
676-679 |
MD |
denotes |
can |
T349 |
680-682 |
VB |
denotes |
be |
T350 |
688-690 |
TO |
denotes |
to |
T351 |
698-706 |
VB |
denotes |
activate |
T352 |
691-697 |
CC |
denotes |
either |
T353 |
707-709 |
CC |
denotes |
or |
T354 |
710-720 |
VB |
denotes |
inactivate |
T355 |
721-726 |
NNS |
denotes |
genes |
T356 |
727-739 |
RB |
denotes |
specifically |
T357 |
740-742 |
IN |
denotes |
in |
T358 |
743-753 |
VBG |
denotes |
developing |
T359 |
754-760 |
NNS |
denotes |
joints |
T360 |
760-761 |
. |
denotes |
. |
T361 |
761-1014 |
sentence |
denotes |
Expression of Cre recombinase from Gdf5 bacterial artificial chromosome clones leads to specific activation or inactivation of floxed target genes in developing joints, including early joint interzones, adult articular cartilage, and the joint capsule. |
T362 |
762-772 |
NN |
denotes |
Expression |
T363 |
841-846 |
VBZ |
denotes |
leads |
T364 |
773-775 |
IN |
denotes |
of |
T365 |
776-779 |
NN |
denotes |
Cre |
T366 |
780-791 |
NN |
denotes |
recombinase |
T367 |
792-796 |
IN |
denotes |
from |
T368 |
797-801 |
NN |
denotes |
Gdf5 |
T369 |
823-833 |
NN |
denotes |
chromosome |
T370 |
802-811 |
JJ |
denotes |
bacterial |
T371 |
812-822 |
JJ |
denotes |
artificial |
T372 |
834-840 |
NNS |
denotes |
clones |
T373 |
847-849 |
IN |
denotes |
to |
T374 |
850-858 |
JJ |
denotes |
specific |
T375 |
859-869 |
NN |
denotes |
activation |
T376 |
870-872 |
CC |
denotes |
or |
T377 |
873-885 |
NN |
denotes |
inactivation |
T378 |
886-888 |
IN |
denotes |
of |
T379 |
889-895 |
VBN |
denotes |
floxed |
T380 |
903-908 |
NNS |
denotes |
genes |
T381 |
896-902 |
NN |
denotes |
target |
T382 |
909-911 |
IN |
denotes |
in |
T383 |
912-922 |
VBG |
denotes |
developing |
T384 |
923-929 |
NNS |
denotes |
joints |
T385 |
929-931 |
, |
denotes |
, |
T386 |
931-940 |
VBG |
denotes |
including |
T387 |
941-946 |
JJ |
denotes |
early |
T388 |
953-963 |
NNS |
denotes |
interzones |
T389 |
947-952 |
NN |
denotes |
joint |
T390 |
963-965 |
, |
denotes |
, |
T391 |
965-970 |
NN |
denotes |
adult |
T392 |
981-990 |
NN |
denotes |
cartilage |
T393 |
971-980 |
JJ |
denotes |
articular |
T394 |
990-992 |
, |
denotes |
, |
T395 |
992-995 |
CC |
denotes |
and |
T396 |
996-999 |
DT |
denotes |
the |
T397 |
1006-1013 |
NN |
denotes |
capsule |
T398 |
1000-1005 |
NN |
denotes |
joint |
T399 |
1013-1014 |
. |
denotes |
. |
T400 |
1014-1104 |
sentence |
denotes |
We have used this system to test the role of BMP receptor signaling in joint development. |
T401 |
1015-1017 |
PRP |
denotes |
We |
T402 |
1023-1027 |
VBN |
denotes |
used |
T403 |
1018-1022 |
VBP |
denotes |
have |
T404 |
1028-1032 |
DT |
denotes |
this |
T405 |
1033-1039 |
NN |
denotes |
system |
T406 |
1040-1042 |
TO |
denotes |
to |
T407 |
1043-1047 |
VB |
denotes |
test |
T408 |
1048-1051 |
DT |
denotes |
the |
T409 |
1052-1056 |
NN |
denotes |
role |
T410 |
1057-1059 |
IN |
denotes |
of |
T411 |
1060-1063 |
NN |
denotes |
BMP |
T412 |
1073-1082 |
NN |
denotes |
signaling |
T413 |
1064-1072 |
NN |
denotes |
receptor |
T414 |
1083-1085 |
IN |
denotes |
in |
T415 |
1086-1091 |
NN |
denotes |
joint |
T416 |
1092-1103 |
NN |
denotes |
development |
T417 |
1103-1104 |
. |
denotes |
. |
T418 |
1104-1202 |
sentence |
denotes |
Mice with null mutations in Bmpr1a are known to die early in embryogenesis with multiple defects. |
T419 |
1105-1109 |
NNS |
denotes |
Mice |
T420 |
1144-1149 |
VBN |
denotes |
known |
T421 |
1110-1114 |
IN |
denotes |
with |
T422 |
1115-1119 |
JJ |
denotes |
null |
T423 |
1120-1129 |
NNS |
denotes |
mutations |
T424 |
1130-1132 |
IN |
denotes |
in |
T425 |
1133-1139 |
NN |
denotes |
Bmpr1a |
T426 |
1140-1143 |
VBP |
denotes |
are |
T427 |
1150-1152 |
TO |
denotes |
to |
T428 |
1153-1156 |
VB |
denotes |
die |
T429 |
1157-1162 |
RB |
denotes |
early |
T430 |
1163-1165 |
IN |
denotes |
in |
T431 |
1166-1179 |
NN |
denotes |
embryogenesis |
T432 |
1180-1184 |
IN |
denotes |
with |
T433 |
1185-1193 |
JJ |
denotes |
multiple |
T434 |
1194-1201 |
NNS |
denotes |
defects |
T435 |
1201-1202 |
. |
denotes |
. |
T436 |
1202-1403 |
sentence |
denotes |
However, combining a floxed Bmpr1a allele with the Gdf5-Cre driver bypasses this embryonic lethality, and leads to birth and postnatal development of mice missing the Bmpr1a gene in articular regions. |
T437 |
1203-1210 |
RB |
denotes |
However |
T438 |
1270-1278 |
VBZ |
denotes |
bypasses |
T439 |
1210-1212 |
, |
denotes |
, |
T440 |
1212-1221 |
VBG |
denotes |
combining |
T441 |
1222-1223 |
DT |
denotes |
a |
T442 |
1238-1244 |
NN |
denotes |
allele |
T443 |
1224-1230 |
VBN |
denotes |
floxed |
T444 |
1231-1237 |
NN |
denotes |
Bmpr1a |
T445 |
1245-1249 |
IN |
denotes |
with |
T446 |
1250-1253 |
DT |
denotes |
the |
T447 |
1263-1269 |
NN |
denotes |
driver |
T448 |
1254-1258 |
NN |
denotes |
Gdf5 |
T449 |
1259-1262 |
NN |
denotes |
Cre |
T450 |
1258-1259 |
HYPH |
denotes |
- |
T451 |
1279-1283 |
DT |
denotes |
this |
T452 |
1294-1303 |
NN |
denotes |
lethality |
T453 |
1284-1293 |
JJ |
denotes |
embryonic |
T454 |
1303-1305 |
, |
denotes |
, |
T455 |
1305-1308 |
CC |
denotes |
and |
T456 |
1309-1314 |
VBZ |
denotes |
leads |
T457 |
1315-1317 |
IN |
denotes |
to |
T458 |
1318-1323 |
NN |
denotes |
birth |
T459 |
1324-1327 |
CC |
denotes |
and |
T460 |
1328-1337 |
JJ |
denotes |
postnatal |
T461 |
1338-1349 |
NN |
denotes |
development |
T462 |
1350-1352 |
IN |
denotes |
of |
T463 |
1353-1357 |
NNS |
denotes |
mice |
T464 |
1358-1365 |
VBG |
denotes |
missing |
T465 |
1366-1369 |
DT |
denotes |
the |
T466 |
1377-1381 |
NN |
denotes |
gene |
T467 |
1370-1376 |
NN |
denotes |
Bmpr1a |
T468 |
1382-1384 |
IN |
denotes |
in |
T469 |
1385-1394 |
JJ |
denotes |
articular |
T470 |
1395-1402 |
NNS |
denotes |
regions |
T471 |
1402-1403 |
. |
denotes |
. |
T473 |
1404-1408 |
JJS |
denotes |
Most |
T474 |
1409-1415 |
NNS |
denotes |
joints |
T475 |
1428-1432 |
VBP |
denotes |
form |
T476 |
1416-1418 |
IN |
denotes |
in |
T477 |
1419-1422 |
DT |
denotes |
the |
T478 |
1423-1427 |
NN |
denotes |
body |
T479 |
1433-1441 |
RB |
denotes |
normally |
T480 |
1442-1444 |
IN |
denotes |
in |
T481 |
1445-1448 |
DT |
denotes |
the |
T482 |
1449-1456 |
NN |
denotes |
absence |
T483 |
1457-1459 |
IN |
denotes |
of |
T484 |
1460-1466 |
NN |
denotes |
Bmpr1a |
T249 |
83-84 |
sentence |
denotes |
|
R17 |
T247 |
T248 |
amod |
Articular,Cartilage |
R18 |
T248 |
T246 |
pobj |
Cartilage,of |
R19 |
T251 |
T252 |
amod |
Articular,cartilage |
R20 |
T252 |
T253 |
nsubj |
cartilage,plays |
R21 |
T254 |
T255 |
det |
an,role |
R84 |
T320 |
T321 |
advmod |
Here,use |
R85 |
T322 |
T321 |
nsubj |
we,use |
R86 |
T323 |
T324 |
amod |
regulatory,information |
R145 |
T384 |
T382 |
pobj |
joints,in |
R146 |
T385 |
T384 |
punct |
", ",joints |
R147 |
T386 |
T384 |
prep |
including,joints |
R148 |
T387 |
T388 |
amod |
early,interzones |
R149 |
T388 |
T386 |
pobj |
interzones,including |
R150 |
T389 |
T388 |
compound |
joint,interzones |
R151 |
T390 |
T388 |
punct |
", ",interzones |
R152 |
T391 |
T392 |
nmod |
adult,cartilage |
R153 |
T392 |
T388 |
conj |
cartilage,interzones |
R154 |
T393 |
T392 |
amod |
articular,cartilage |
R190 |
T433 |
T434 |
amod |
multiple,defects |
R191 |
T434 |
T432 |
pobj |
defects,with |
R192 |
T435 |
T420 |
punct |
.,known |
R193 |
T437 |
T438 |
advmod |
However,bypasses |
R194 |
T439 |
T438 |
punct |
", ",bypasses |
R195 |
T440 |
T438 |
csubj |
combining,bypasses |
R213 |
T458 |
T457 |
pobj |
birth,to |
R214 |
T459 |
T458 |
cc |
and,birth |
R223 |
T468 |
T464 |
prep |
in,missing |
R224 |
T469 |
T470 |
amod |
articular,regions |
R225 |
T470 |
T468 |
pobj |
regions,in |
R226 |
T471 |
T438 |
punct |
.,bypasses |
R227 |
T473 |
T474 |
amod |
Most,joints |
R228 |
T474 |
T475 |
nsubj |
joints,form |
R229 |
T476 |
T474 |
prep |
in,joints |
R230 |
T477 |
T478 |
det |
the,body |
R9 |
T237 |
T238 |
compound |
BMP,Receptor |
R10 |
T238 |
T240 |
compound |
Receptor,Signaling |
R11 |
T240 |
T241 |
nsubjpass |
Signaling,Required |
R12 |
T242 |
T241 |
auxpass |
Is,Required |
R13 |
T243 |
T241 |
prep |
for,Required |
R14 |
T244 |
T245 |
amod |
Postnatal,Maintenance |
R15 |
T245 |
T243 |
pobj |
Maintenance,for |
R16 |
T246 |
T245 |
prep |
of,Maintenance |
R22 |
T255 |
T253 |
dobj |
role,plays |
R23 |
T256 |
T255 |
amod |
essential,role |
R24 |
T257 |
T253 |
prep |
in,plays |
R25 |
T258 |
T257 |
pobj |
health,in |
R26 |
T259 |
T258 |
cc |
and,health |
R27 |
T260 |
T258 |
conj |
mobility,health |
R28 |
T261 |
T253 |
punct |
", ",plays |
R29 |
T262 |
T253 |
cc |
but,plays |
R30 |
T263 |
T264 |
auxpass |
is,damaged |
R31 |
T264 |
T253 |
conj |
damaged,plays |
R32 |
T265 |
T264 |
advmod |
frequently,damaged |
R33 |
T266 |
T264 |
cc |
or,damaged |
R34 |
T267 |
T264 |
conj |
lost,damaged |
R35 |
T268 |
T267 |
prep |
in,lost |
R36 |
T269 |
T268 |
pobj |
millions,in |
R37 |
T270 |
T269 |
prep |
of,millions |
R38 |
T271 |
T270 |
pobj |
people,of |
R39 |
T272 |
T273 |
dep |
that,develop |
R40 |
T273 |
T271 |
relcl |
develop,people |
R41 |
T274 |
T273 |
dobj |
arthritis,develop |
R42 |
T275 |
T253 |
punct |
.,plays |
R43 |
T277 |
T278 |
det |
The,mechanisms |
R44 |
T278 |
T280 |
nsubjpass |
mechanisms,understood |
R45 |
T279 |
T278 |
amod |
molecular,mechanisms |
R46 |
T281 |
T282 |
dep |
that,create |
R47 |
T282 |
T278 |
relcl |
create,mechanisms |
R48 |
T283 |
T282 |
cc |
and,create |
R49 |
T284 |
T282 |
conj |
maintain,create |
R50 |
T285 |
T286 |
det |
this,layer |
R51 |
T286 |
T284 |
dobj |
layer,maintain |
R52 |
T287 |
T286 |
amod |
thin,layer |
R53 |
T288 |
T286 |
prep |
of,layer |
R54 |
T289 |
T288 |
pobj |
cartilage,of |
R55 |
T290 |
T291 |
dep |
that,covers |
R56 |
T291 |
T286 |
relcl |
covers,layer |
R57 |
T292 |
T293 |
det |
the,surface |
R58 |
T293 |
T291 |
dobj |
surface,covers |
R59 |
T294 |
T293 |
prep |
of,surface |
R60 |
T295 |
T294 |
pobj |
bones,of |
R61 |
T296 |
T291 |
prep |
in,covers |
R62 |
T297 |
T298 |
compound |
joint,regions |
R63 |
T298 |
T296 |
pobj |
regions,in |
R64 |
T299 |
T280 |
auxpass |
are,understood |
R65 |
T300 |
T280 |
advmod |
poorly,understood |
R66 |
T301 |
T280 |
punct |
", ",understood |
R67 |
T302 |
T303 |
prep |
in,been |
R68 |
T303 |
T280 |
advcl |
been,understood |
R69 |
T304 |
T302 |
amod |
part,in |
R70 |
T305 |
T303 |
mark |
because,been |
R71 |
T306 |
T303 |
nsubj |
tools,been |
R72 |
T307 |
T308 |
aux |
to,manipulate |
R73 |
T308 |
T306 |
advcl |
manipulate,tools |
R74 |
T309 |
T310 |
compound |
gene,expression |
R75 |
T310 |
T308 |
dobj |
expression,manipulate |
R76 |
T311 |
T312 |
advmod |
specifically,in |
R77 |
T312 |
T308 |
prep |
in,manipulate |
R78 |
T313 |
T314 |
det |
this,tissue |
R79 |
T314 |
T312 |
pobj |
tissue,in |
R80 |
T315 |
T303 |
aux |
have,been |
R81 |
T316 |
T303 |
neg |
not,been |
R82 |
T317 |
T303 |
acomp |
available,been |
R83 |
T318 |
T280 |
punct |
.,understood |
R87 |
T324 |
T321 |
dobj |
information,use |
R88 |
T325 |
T324 |
prep |
from,information |
R89 |
T326 |
T327 |
det |
the,gene |
R90 |
T327 |
T325 |
pobj |
gene,from |
R91 |
T328 |
T327 |
compound |
mouse,gene |
R92 |
T329 |
T327 |
compound |
Gdf5,gene |
R93 |
T330 |
T331 |
punct |
(,member |
R95 |
T332 |
T331 |
det |
a,member |
R96 |
T333 |
T334 |
nmod |
bone,protein |
R97 |
T334 |
T331 |
nmod |
protein,member |
R98 |
T335 |
T334 |
amod |
morphogenetic,protein |
R99 |
T336 |
T337 |
punct |
[,BMP |
R100 |
T337 |
T334 |
appos |
BMP,protein |
R101 |
T338 |
T337 |
punct |
],BMP |
R102 |
T339 |
T331 |
compound |
family,member |
R103 |
T340 |
T331 |
punct |
),member |
R104 |
T341 |
T342 |
aux |
to,develop |
R105 |
T342 |
T321 |
advcl |
develop,use |
R106 |
T343 |
T344 |
amod |
new,lines |
R107 |
T344 |
T342 |
dobj |
lines,develop |
R108 |
T345 |
T344 |
compound |
mouse,lines |
R109 |
T346 |
T347 |
dep |
that,used |
R110 |
T347 |
T344 |
relcl |
used,lines |
R111 |
T348 |
T347 |
aux |
can,used |
R112 |
T349 |
T347 |
auxpass |
be,used |
R113 |
T350 |
T351 |
aux |
to,activate |
R114 |
T351 |
T347 |
advcl |
activate,used |
R115 |
T352 |
T351 |
preconj |
either,activate |
R116 |
T353 |
T351 |
cc |
or,activate |
R117 |
T354 |
T351 |
conj |
inactivate,activate |
R118 |
T355 |
T354 |
dobj |
genes,inactivate |
R119 |
T356 |
T354 |
advmod |
specifically,inactivate |
R120 |
T357 |
T354 |
prep |
in,inactivate |
R121 |
T358 |
T359 |
amod |
developing,joints |
R122 |
T359 |
T357 |
pobj |
joints,in |
R123 |
T360 |
T321 |
punct |
.,use |
R124 |
T362 |
T363 |
nsubj |
Expression,leads |
R125 |
T364 |
T362 |
prep |
of,Expression |
R126 |
T365 |
T366 |
compound |
Cre,recombinase |
R127 |
T366 |
T364 |
pobj |
recombinase,of |
R128 |
T367 |
T366 |
prep |
from,recombinase |
R129 |
T368 |
T369 |
nmod |
Gdf5,chromosome |
R130 |
T369 |
T372 |
compound |
chromosome,clones |
R131 |
T370 |
T371 |
amod |
bacterial,artificial |
R132 |
T371 |
T369 |
amod |
artificial,chromosome |
R133 |
T372 |
T367 |
pobj |
clones,from |
R134 |
T373 |
T363 |
prep |
to,leads |
R135 |
T374 |
T375 |
amod |
specific,activation |
R136 |
T375 |
T373 |
pobj |
activation,to |
R137 |
T376 |
T375 |
cc |
or,activation |
R138 |
T377 |
T375 |
conj |
inactivation,activation |
R139 |
T378 |
T375 |
prep |
of,activation |
R140 |
T379 |
T380 |
amod |
floxed,genes |
R141 |
T380 |
T378 |
pobj |
genes,of |
R142 |
T381 |
T380 |
compound |
target,genes |
R143 |
T382 |
T363 |
prep |
in,leads |
R144 |
T383 |
T384 |
amod |
developing,joints |
R155 |
T394 |
T392 |
punct |
", ",cartilage |
R156 |
T395 |
T392 |
cc |
and,cartilage |
R157 |
T396 |
T397 |
det |
the,capsule |
R158 |
T397 |
T392 |
conj |
capsule,cartilage |
R159 |
T398 |
T397 |
compound |
joint,capsule |
R160 |
T399 |
T363 |
punct |
.,leads |
R161 |
T401 |
T402 |
nsubj |
We,used |
R162 |
T403 |
T402 |
aux |
have,used |
R163 |
T404 |
T405 |
det |
this,system |
R164 |
T405 |
T402 |
dobj |
system,used |
R165 |
T406 |
T407 |
aux |
to,test |
R166 |
T407 |
T402 |
advcl |
test,used |
R167 |
T408 |
T409 |
det |
the,role |
R168 |
T409 |
T407 |
dobj |
role,test |
R169 |
T410 |
T409 |
prep |
of,role |
R170 |
T411 |
T412 |
compound |
BMP,signaling |
R171 |
T412 |
T410 |
pobj |
signaling,of |
R172 |
T413 |
T412 |
compound |
receptor,signaling |
R173 |
T414 |
T409 |
prep |
in,role |
R174 |
T415 |
T416 |
compound |
joint,development |
R175 |
T416 |
T414 |
pobj |
development,in |
R176 |
T417 |
T402 |
punct |
.,used |
R177 |
T419 |
T420 |
nsubjpass |
Mice,known |
R178 |
T421 |
T419 |
prep |
with,Mice |
R179 |
T422 |
T423 |
amod |
null,mutations |
R180 |
T423 |
T421 |
pobj |
mutations,with |
R181 |
T424 |
T423 |
prep |
in,mutations |
R182 |
T425 |
T424 |
pobj |
Bmpr1a,in |
R183 |
T426 |
T420 |
auxpass |
are,known |
R184 |
T427 |
T428 |
aux |
to,die |
R185 |
T428 |
T420 |
xcomp |
die,known |
R186 |
T429 |
T428 |
advmod |
early,die |
R187 |
T430 |
T429 |
prep |
in,early |
R188 |
T431 |
T430 |
pobj |
embryogenesis,in |
R189 |
T432 |
T428 |
prep |
with,die |
R196 |
T441 |
T442 |
det |
a,allele |
R197 |
T442 |
T440 |
dobj |
allele,combining |
R198 |
T443 |
T442 |
amod |
floxed,allele |
R199 |
T444 |
T442 |
compound |
Bmpr1a,allele |
R200 |
T445 |
T440 |
prep |
with,combining |
R201 |
T446 |
T447 |
det |
the,driver |
R202 |
T447 |
T445 |
pobj |
driver,with |
R203 |
T448 |
T449 |
compound |
Gdf5,Cre |
R204 |
T449 |
T447 |
compound |
Cre,driver |
R205 |
T450 |
T449 |
punct |
-,Cre |
R206 |
T451 |
T452 |
det |
this,lethality |
R207 |
T452 |
T438 |
dobj |
lethality,bypasses |
R208 |
T453 |
T452 |
amod |
embryonic,lethality |
R209 |
T454 |
T438 |
punct |
", ",bypasses |
R210 |
T455 |
T438 |
cc |
and,bypasses |
R211 |
T456 |
T438 |
conj |
leads,bypasses |
R212 |
T457 |
T456 |
prep |
to,leads |
R215 |
T460 |
T461 |
amod |
postnatal,development |
R216 |
T461 |
T458 |
conj |
development,birth |
R217 |
T462 |
T458 |
prep |
of,birth |
R218 |
T463 |
T462 |
pobj |
mice,of |
R219 |
T464 |
T463 |
acl |
missing,mice |
R220 |
T465 |
T466 |
det |
the,gene |
R221 |
T466 |
T464 |
dobj |
gene,missing |
R222 |
T467 |
T466 |
compound |
Bmpr1a,gene |
R231 |
T478 |
T476 |
pobj |
body,in |
R232 |
T479 |
T475 |
advmod |
normally,form |
R233 |
T480 |
T475 |
prep |
in,form |
R234 |
T481 |
T482 |
det |
the,absence |
R235 |
T482 |
T480 |
pobj |
absence,in |
R236 |
T483 |
T482 |
prep |
of,absence |
R94 |
T331 |
T327 |
parataxis |
member,gene |