Comparative studies at the genome level have revealed conserved sequences for appetite regulators across mammalian and fish species, indicating potentially conserved biological functions. Whereas the genome of all vertebrates is the result of two rounds (2R) of whole genome duplication (WGD) occurring in early vertebrate evolution, additional WGDs occurred in the teleost fish ancestor (3R) and most recently in certain teleost lineages (4R, e.g., salmonidae and cyprinidae), leading to the presence of increased gene copy numbers and multiple protein isoforms with potentially different physiological functions (Glasauer and Neuhauss, 2014), making the fish model potentially more complex. One must thus keep in mind that fish feeding-regulating hormones might not always have the same function as their mammalian homologs.