In rainbow trout, CRF and urotensin 1 are anorexigenic, as ICV injections of either peptides inhibit feeding (Ortega et al., 2013). In addition, hypoxia stress suppresses appetite and increases forebrain CRF and urotensin mRNA levels, suggesting that, in Salmoniformes, CRF-related peptides might mediate the hypoxia-induced reduction in food intake (Bernier and Craig, 2005).