Figure 3  Somatically generated Arg codons often arise at germline CDR AGY Ser codons in antiviral immune responses. (A) Sequences and analyses from two studies of anti-H1N1 antibodies, as described in Section “Materials and Methods.” Heavy and light chains for a particular clone were combined to generate data for the graphs. The data combine the results of CDR and FR analyses. Any → Arg indicates a mutation at any non-Arg codon that gives rise to an Arg codon. Ser → Arg indicates an AGY Ser codon to Arg codon mutation. Numbers inside graphs indicate number of clones that were analyzed (heavy plus light chain). (B) Bars represent the average number of indicated replacement mutations among antiviral antibodies (heavy or light chain genes). Influenza #1 (n = 92), Influenza #2 (n = 98), Rhinovirus (n = 12), Avian Influenza (n = 27), West Nile (n = 6), Dengue virus (n = 4), Hepatitis A, B and C (n = 59).