Cumulative concentration response curves of 5-HT and Ang II for both HFD fed rat thoracic aortae showed an increase in Emax (Fig 2 and 3) with out any change in pD2 values when compared to NPD fed rats (Table 2). There was no significant change in both Emax and pD2 values with KCl in both groups (data not shown). The order of potency of agonists in both groups was Ang II>5-HT>KCl.