WES
Three micrograms of genomic DNA were processed using a SureSelect v4+UTRs or v5+UTRs kit according to the manufacturer's instructions. Captured DNA was sequenced using a HiSeq 2000 (Illumina, San Diego, CA). Sequences were aligned to the human reference genome (NCBI37/hg19) using the Burrows–Wheeler Aligner.18 Variant calling was performed using SAMtools.19 Variants were annotated using in‐house scripts, which provided the variants list. Previously known variants were annotated from the 1000 Genomes Project and dbSNP137.