Figure 1  Flow chart for genetic tests, selection of patients, and exome‐based shared variants detection (ESVD) system among the first case series of 372 Charcot–Marie–Tooth (CMT) patients, we selected 163 patients with presumed autosomal‐recessive or sporadic CMT and no known genetic etiology. Using the ESVD system, we automatically performed variant filtering under the conditions (1) to (6). Subsequently, we identified 5 patients with a mutation in the MME gene by the shared variants/genes pickup system. AD = autosomal‐dominant; AR = autosomal‐recessive; SNV = single‐nucleotide variation; MAF = minor allele frequency.