Unlike Illumina microarrays, kinome microarrays do not provide a statistically large number of within-array replicates, yet the number of within-array replicates in these arrays is more than Affymetrix arrays. Previously, kinome microarrays provided 2 to 3 replicates for each probe [23]. This number is now about 9 replicates for each probe, which is three times more than in Affymetrix arrays. This difference between the numbers of within-array replicates may affect the ability of different variance stabilizing methods in eliminating heterogeneity of variance in kinome arrays.